Simulation of the response of the inner hair cell stereocilia bundle to an acoustical stimulus.
Simulation of the response of the inner hair cell stereocilia bundle to an acoustical stimulus.
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DOI：
10.1371/journal.pone.0018161
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发表时间：
2011-03-31
期刊：
影响因子：
3.7
通讯作者：
Chadwick RS
中科院分区：
文献类型：
--
作者：
Smith ST;Chadwick RS
哺乳动物的听力依赖于内毛细胞静纤毛束中包含的耳蜗流体动力传感器。据推测，声刺激引起流体剪切驱动运动之间的覆膜和网状层偏转束。据推测，离子通道是通过分子门打开的，分子门感知尖端链接中的张力，尖端链接连接相邻的阶梯状行的静纤毛。然而，关于流体和束如何相互作用，几乎一无所知。在这里，我们展示了使用我们的微流体模型如何每排静纤毛及其相关的尖端链接和门移动响应于声输入，诱导的网状层的轨道运动。该模型证实了在听力中定位的覆膜的关键作用，并解释了这一膜如何放大和放大尖端链接中的峰值张力的时间。静纤毛的旋转和长度的变化都需要尖端链接张力的峰值同步。静纤毛长度的变化发生在响应于垂直于振荡流体剪切流的加速度。模拟表明，纳米涡旋在行之间形成，以促进离子扩散到通道中，显示了大自然如何设计出一种方法来解决工程微流体设备中持续存在的扩散混合问题。
Mammalian hearing relies on a cochlear hydrodynamic sensor embodied in the inner hair cell stereocilia bundle. It is presumed that acoustical stimuli induce a fluid shear-driven motion between the tectorial membrane and the reticular lamina to deflect the bundle. It is hypothesized that ion channels are opened by molecular gates that sense tension in tip-links, which connect adjacent stepped rows of stereocilia. Yet almost nothing is known about how the fluid and bundle interact. Here we show using our microfluidics model how each row of stereocilia and their associated tip links and gates move in response to an acoustical input that induces an orbital motion of the reticular lamina. The model confirms the crucial role of the positioning of the tectorial membrane in hearing, and explains how this membrane amplifies and synchronizes the timing of peak tension in the tip links. Both stereocilia rotation and length change are needed for synchronization of peak tip link tension. Stereocilia length change occurs in response to accelerations perpendicular to the oscillatory fluid shear flow. Simulations indicate that nanovortices form between rows to facilitate diffusion of ions into channels, showing how nature has devised a way to solve the diffusive mixing problem that persists in engineered microfluidic devices.
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影响因子：
2
作者：
CHORIN, AJ
通讯作者：
CHORIN, AJ
影响因子：
2.8
作者：
FREEMAN, DM;WEISS, TF
通讯作者：
WEISS, TF
DOI：
10.1073/pnas.0507231103
发表时间：
2006-02-07
影响因子：
11.1
作者：
Fridberger, A;Tomo, I;de Monvel, JB
通讯作者：
de Monvel, JB
影响因子：
64.8
作者：
COREY, DP;HUDSPETH, AJ
通讯作者：
HUDSPETH, AJ
微管和肌动蛋白丝的弯曲刚度是根据形状的热波动测得的。
DOI：
10.1083/jcb.120.4.923
发表时间：
1993-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gittes F;Mickey B;Nettleton J;Howard J
通讯作者：
Howard J