Zampanolide, a new cytotoxic macrolide from a marine sponge
Zampanolide, a new cytotoxic macrolide from a marine sponge
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DOI：
10.1016/0040-4039(96)01149-5
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发表时间：
1996-07-29
影响因子：
1.8
通讯作者：
Higa, T
中科院分区：
文献类型：
--
作者：
Tanaka, J;Higa, T
一种新型 20 元大环内酯 Zampanolide (3) 与 latrunculin A (1) 一起从先前产生 I 和 laulimalide (2) 的不同海绵集合中分离出来。 3的总体结构通过2D NMR确定，部分立体化学通过NOE分析确定。它是一种高度不饱和的 20 元大环内酯，含有罕见的甲醇胺官能团。 Zampanolide 对多种肿瘤细胞系表现出有效的细胞毒性。版权所有 (C) 1996 爱思唯尔科学有限公司
A novel 20-membered macrolide, zampanolide (3), has been isolated together with latrunculin A (1) from a different collection of the sponge which previously yielded I and laulimalide (2). The gross structure of 3 was determined by 2D NMR and partial stereochemistry by NOE analysis. It is a highly unsaturated 20-membered macrolide containing an uncommon carbinol amine functionality. Zampanolide showed potent cytotoxicity against several tumor cell lines. Copyright (C) 1996 Elsevier Science Ltd