Incidence of Trisomy 8 and 9, Deletion of D13s319 and D20s108 Loci and Bcr/abl Translocation in Non-treated Essential Thrombocythemia Patients: an Analysis of Bone Marrow Cells Using Interphase Fluorescence in Situ Hybridization
Incidence of Trisomy 8 and 9, Deletion of D13s319 and D20s108 Loci and Bcr/abl Translocation in Non-treated Essential Thrombocythemia Patients: an Analysis of Bone Marrow Cells Using Interphase Fluorescence in Situ Hybridization
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未经治疗的原发性血小板增多症患者中 8 号和 9 三体性、D13s319 和 D20s108 位点缺失以及 Bcr/abl 易位的发生率：使用间期荧光原位杂交分析骨髓细胞
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
G. Lambertenghi‐Deliliers
中科院分区：
文献类型：
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作者：
G. Pruneri;N. Fracchiolla;A. Cortelezzi;M. Ponzoni;P. Maisonneuve;G. Lambertenghi‐Deliliers
原始细胞百分比、M/E比率、FAB亚型，但不是细胞周期蛋白E IR，与存活率显著相关（表1）。多因素分析显示IPSS（p=0.0068）和RAEB-t亚型（p=0.001）是生存的独立预测因子。有趣的是，当生存分析仅限于RA/RARS的低风险子集时，年龄（p=0.0287），IPSS（p=0.0113）和FAB亚型（RA与RARS，p=0.0563）变量与生存相关。在多变量分析中，年龄变量（p=0.0284）是RA/RARS患者生存率的唯一独立预测因素。尽管细胞周期蛋白E IR在具有不良临床病程的RA/RARS中更普遍，但这种趋势在单变量（p=0.0759）或多变量（p=0.0604）分析中均未达到统计学显著性，可能是因为病例数相对较少。Giancarlo Pruneri，* Nicola Fracchiolla，# Agostino Cortelezzi，# Maurilio Ponzoni，@帕特里克Maisonneuve，° Giorgio Lambertenghi-Deliliers# * 米兰大学医学院欧洲肿瘤研究所病理学和实验室医学部，°流行病学和生物统计学部; #米兰大学医学院血液学部，Ospedale Maggiore Policlinico，IRCCS; @病理学部，S.拉斐尔H科学研究所，米兰，意大利
percentage of blasts, M/E ratio, FAB subtype, but not cyclin E IR, were significantly associated with survival (Table 1). Multivariate analysis showed that IPSS (p=0.0068) and RAEB-t subtype (p=0.001) were independent predictors of survival. Interestingly, when the survival analysis was restricted to the low-risk subset of RA/RARS, the variables of age (p=0.0287), IPSS (p=0.0113) and FAB subtype (RA vs. RARS, p=0.0563) were associated with survival. At multivariate analysis, the variable of age (p=0.0284) was the only independent predictor of survival in RA/RARS. Although cyclin E IR was more prevalent in RA/RARS with an adverse clinical course, this trend did not achieve statistical significance, either at univariate (p=0.0759), or multivariate (p=0.0604) analysis, possibly because of the relatively small number of cases. Giancarlo Pruneri,* Nicola Fracchiolla,# Agostino Cortelezzi,# Maurilio Ponzoni,@ Patrick Maisonneuve,° Giorgio Lambertenghi-Deliliers# *Division of Pathology and Laboratory Medicine,°Epidemiology and Biostatistics, European Institute of Oncology, University of Milan, School of Medicine; #Division of Hematology, Ospedale Maggiore Policlinico, IRCCS, University of Milan, School of Medicine; @Division of Pathology, S. Raffaele H Scientific Institute, Milan, Italy
骨髓增生异常综合征患者的髓内造血细胞凋亡可能很大：从骨髓抽吸物的高密度部分中回收的凋亡细胞。
影响因子：
20.3
作者：
Shetty,V;Hussaini,S;Broady-Robinson,L;Allampallam,K;Mundle,S;Borok,R;Broderick,E;Mazzoran,L;Zorat,F;Raza,A
通讯作者：
Raza,A