APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.
APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.
复制标题
DOI：
10.1007/s11682-016-9522-9
复制
发表时间：
2017-02
影响因子：
3.2
通讯作者：
Potter GG
中科院分区：
文献类型：
--
作者：
Taylor WD;Boyd B;Turner R;McQuoid DR;Ashley-Koch A;MacFall JR;Saleh A;Potter GG
APOE ε4等位基因与老年人的认知缺陷和脑萎缩相关，但在年轻人中的研究结果不一。我们研究了APOE基因型对年轻人认知和大脑结构的影响，以及基因型影响是否因年龄和抑郁症的存在而不同。157名20-50岁的成年人（32% ε4携带者，46%抑郁）完成了神经心理学测试，其中131人还完成了3 T颅脑MRI。我们没有观察到APOE基因型对认知能力或结构MRI测量的直接影响。在执行功能方面，观察到一个显著的基因型与年龄的相互作用，其中年龄对ε4携带者的执行功能的影响较小。内嗅皮层、前扣带皮层的喙侧和尾侧以及海马旁回也观察到了类似的相互作用，在ε4携带者中，年龄对区域体积的影响降低。APOE基因型与抑郁症诊断之间无显著交互作用。ε4等位基因使年轻人受益，使他们能够保持执行功能的表现和扣带和颞叶皮层区域的体积随着年龄的增长，至少到50岁。
The APOE ε4 allele is associated with cognitive deficits and brain atrophy in older adults, but studies in younger adults are mixed. We examined APOE genotype effects on cognition and brain structure in younger adults and whether genotype effects differed by age and with presence of depression. 157 adults (32% ε4 carriers, 46% depressed) between 20–50 years of age completed neuropsychological testing, 131 of which also completed 3T cranial MRI. We did not observe a direct effect of APOE genotype on cognitive performance or structural MRI measures. A significant genotype by age interaction was observed for executive function, where age had less of an effect on executive function in ε4 carriers. Similar interactions were observed for the entorhinal cortex, rostral and caudal anterior cingulate cortex and parahippocampal gyrus, where the effect of age on regional volumes was reduced in ε4 carriers. There were no significant interactions between APOE genotype and depression diagnosis. The ε4 allele benefits younger adults by allowing them to maintain executive function performance and volumes of cingulate and temporal cortex regions with aging, at least through age fifty years.