Guanylin peptides and colorectal cancer (CRC)
Guanylin peptides and colorectal cancer (CRC)
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DOI：
10.1016/j.biopha.2007.04.010
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发表时间：
2008-02-01
影响因子：
7.5
通讯作者：
Camici, Marcello
中科院分区：
文献类型：
--
作者：
Camici, Marcello
鸟苷酰-C受体激动剂，如鸟苷素/尿鸟苷素，不仅与肠上皮细胞生理学相关，而且与结直肠癌肿瘤发生相关。鸟苷酸环化酶-C受体激活第二胞内信使环鸟苷一磷酸导致涉及磷酸二酯酶、离子通道和蛋白激酶的复杂胞内信号级联。在对相关新知识进行分析性回顾后，讨论了结直肠癌的新诊断和治疗方法。(c)2007年由Elsevier Masson SAS出版。
Agonists of guanylyl-C receptor, such as guanylin/uroguanylin, are correlated not only with the intestinal cell epithelial physiology but also with the colorectal cancer tumorigenesis. Activation of the second intracellular messenger cyclic guanosine monophosphate by guanylyl cyclase-C receptor results in a complex intracellular signalling cascade involving the phosphodiesterase, the ion channels and the protein kinase. After an analytical review of relevant new knowledge, new diagnostic and therapeutic approaches for colorectal cancer are discussed. (c) 2007 Published by Elsevier Masson SAS.