Association of attitudes and beliefs towards antiretroviral therapy with HIV-seroprevalence in the general population of Kisumu, Kenya.
Association of attitudes and beliefs towards antiretroviral therapy with HIV-seroprevalence in the general population of Kisumu, Kenya.
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DOI：
10.1371/journal.pone.0004573
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Bukusi EA
中科院分区：
文献类型：
--
作者：
Cohen CR;Montandon M;Carrico AW;Shiboski S;Bostrom A;Obure A;Kwena Z;Bailey RC;Nguti R;Bukusi EA
自从抗逆转录病毒疗法（ART）在发达国家出现以来，无保护性行为的流行以及性传播感染（STI）和艾滋病毒的发病率有所增加。我们假设，随着艾滋病毒治疗规模的扩大，撒哈拉以南非洲地区可能也会出现类似的现象。我们在肯尼亚基苏木进行了一项以人口为基础的调查。参与者完成了一次采访，其中包括人口统计数据以及与 ART 相关的态度和信念 (AB)，然后接受了 HIV 血清学检测。 AB 关于 ART 的探索性和验证性因素分析表明了两个因素：1）与 ART 相关的风险补偿（由于 ART 可用，性风险增加）； 2) 人们认为，既然有了抗逆转录病毒疗法，艾滋病毒就更容易控制了。在控制年龄后，使用逻辑回归来确定这些因素与 HIV 血清流行率的关联。 1,844 名 15-49 岁的受访者中，有 1,655 名 (90%) 同意参与这项研究，其中包括 749 名男性和 906 名女性。大多数参与者（n = 1164；71%）听说过 ART。在听说过 ART 的人中，23% 认为 ART 可以治愈 HIV。 ART 相关风险补偿（调整后 (A)OR = 1.45，95% CI 1.16–1.81）以及 ART 治愈 HIV 的信念（AOR = 2.14，95% CI 1.22–3.76）与控制年龄后男性而非女性 HIV 血清阳性率增加相关。特别是，与 ART 相关的风险补偿与年轻（15-24 岁）男性的 HIV 血清流行率增加相关（OR = 1.56；95% CI 1.12-2.19）。与抗逆转录病毒疗法相关的风险补偿以及认为抗逆转录病毒疗法可以治愈艾滋病毒的信念与男性艾滋病毒血清流行率增加有关，但与女性无关。撒哈拉以南非洲地区针对普通人群的艾滋病毒预防计划应包括有关抗逆转录病毒治疗的教育信息，并解决在抗逆转录病毒治疗日益普及的时代，人们对艾滋病毒的看法不断变化的问题。
Since antiretroviral therapy (ART) became available in the developed world, the prevalence of unprotected sex and the incidence of sexually transmitted infections (STIs) and HIV have increased. We hypothesized that a similar phenomenon may be occurring in sub-Saharan Africa concomitant with the scale-up of HIV treatment. We conducted a general population-based survey in Kisumu, Kenya. Participants completed an interview that included demographics as well as ART-related attitudes and beliefs (AB) and then underwent HIV serological testing. Exploratory and confirmatory factor analyses of AB about ART indicated two factors: 1) ART-related risk compensation (increased sexual risk taking now that ART is available); and 2) a perception that HIV is more controllable now that ART is available. Logistic regression was used to determine associations of these factors with HIV-seroprevalence after controlling for age. 1,655 (90%) of 1,844 people aged 15–49 contacted, including 749 men and 906 women, consented to participate in the study. Most participants (n = 1164; 71%) had heard of ART. Of those who had heard of ART, 23% believed ART was a cure for HIV. ART-related risk compensation (Adjusted (A)OR = 1.45, 95% CI 1.16–1.81), and a belief that ART cures HIV (AOR = 2.14, 95% CI 1.22–3.76) were associated with an increased HIV seroprevalence in men but not women after controlling for age. In particular, ART-related risk compensation was associated with an increased HIV-seroprevalence in young (aged 15–24 years) men (OR = 1.56; 95% CI 1.12–2.19). ART-related risk compensation and a belief that ART cures HIV were associated with an increased HIV seroprevalence among men but not women. HIV prevention programs in sub-Saharan Africa that target the general population should include educational messages about ART and address the changing beliefs about HIV in the era of greater ART availability.
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影响因子：
3.7
作者：
Nagelkerke, Nico J. D.;Moses, Stephen;Bailey, Robert C.
通讯作者：
Bailey, Robert C.
影响因子：
3.6
作者：
Ferguson, A;Pere, M;Moses, S
通讯作者：
Moses, S
影响因子：
3.8
作者：
Grémy, I;Beltzer, N
通讯作者：
Beltzer, N
DOI：
10.1363/3100605
发表时间：
2005-03-01
期刊：
INTERNATIONAL FAMILY PLANNING PERSPECTIVES
影响因子：
--
作者：
Luke, N
通讯作者：
Luke, N
影响因子：
3.8
作者：
Ostrow, DE;Fox, KJ;Strathdee, SA
通讯作者：
Strathdee, SA