The effect of previous alcohol abuse on cognitive function in HIV infection
The effect of previous alcohol abuse on cognitive function in HIV infection
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DOI：
10.1176/appi.ajp.161.2.249
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发表时间：
2004-02-01
影响因子：
17.7
通讯作者：
Bornstein, RA
中科院分区：
文献类型：
--
作者：
Green, JE;Saveanu, RV;Bornstein, RA
目的：作者的目标是研究对认知功能的HIV感染和酗酒史的相互作用的潜在影响。方法：受试者为30名HIV阴性和50名HIV阳性男性，有和没有酗酒史。其中33名男性（12名HIV阴性和21名HIV阳性）有酗酒史，47名（18名HIV阴性和29名HIV阳性）从未酗酒。每个受试者的饮酒史是通过使用基于DSM-III-R结构化临床访谈和定量方法的综合征方法获得的。每个受试者都接受了一系列神经心理学测试，评估语言推理、反应时间、智力、记忆力和灵活性。受试者进行比较，然后总结神经心理损伤rating.Results：有没有显着差异，在CD 4水平，年龄，教育，抑郁，焦虑，或其他药物滥用史之间的HIV阳性和HIV阴性组，有和没有酗酒史。过去的酗酒和HIV感染对认知功能有显著影响，在言语推理、听觉处理和反应时间方面有显著的相互作用。这表明，艾滋病毒感染和酗酒史对高级认知功能的某些方面有独立的影响，但可能对其他认知领域有协同作用。在HIV阴性的受试者中，有和没有酗酒史的受试者之间的认知功能没有差异。在HIV阳性的受试者中，那些有酗酒史的人在言语智商，言语推理和反应时间的测试中表现更差。结论：以前的酒精滥用和HIV感染对认知有相加和交互作用。有酗酒史的人在HIV感染的情况下可能有更大的认知功能障碍风险。
Objective: The authors' goal was to study the potential effect on cognitive function of an interaction of HIV infection and a history of alcohol abuse.Method: The subjects were 30 HIV-negative and 50 HIV-positive men with and without a past history of alcohol abuse. Thirty-three of the men (12 HIV negative and 21 HIV positive) had a past history of alcohol abuse, and 47 (18 HIV negative and 29 HIV positive) had never abused alcohol. Each subject's history of alcohol use was obtained by using a syndromal approach based on the Structured Clinical Interview for DSM-III-R and a quantitative approach. Each subject was given a battery of neuropsychological tests assessing verbal reasoning, reaction time, intelligence, memory, and dexterity. The subjects were then compared on a summary neuropsychological impairment rating.Results: There were no significant differences in CD4 level, age, education, depression, anxiety, or other drug abuse history between the HIV-positive and HIV-negativegroups with and without a history of alcohol abuse. Significant effects on cognitive function were found for past alcohol abuse and HIV infection, with significant interactions in verbal reasoning, auditory processing, and reaction time. This demonstrates that HIV infection and a history of alcohol abuse have independent effects on some aspects of higher cognitive function but may have synergistic effects on other cognitive domains. in the HIV-negative subjects there were no differences in cognitive function between subjects with and without a history of alcohol abuse. Among the HIV-positive subjects, those with a history of alcohol abuse performed more poorly on tests of verbal IQ, verbal reasoning, and reaction time.Conclusions: There are both additive and interactive effects of previous alcohol abuse and HIV infection on cognition. Individuals with a history of past alcohol abuse may be at greater risk for cognitive dysfunction in the context of HIV infection.