Prefrontal cortex function in nonpsychotic siblings of individuals with schizophrenia
Prefrontal cortex function in nonpsychotic siblings of individuals with schizophrenia
复制标题
DOI：
10.1016/j.biopsych.2007.05.007
复制
发表时间：
2008-03-01
影响因子：
10.6
通讯作者：
Barch, Deanna M.
中科院分区：
文献类型：
--
作者：
Delawalla, Zainab;Csernansky, John G.;Barch, Deanna M.
背景：认知功能障碍是精神分裂症的标志性特征。近年来，有研究认为，注意力、工作记忆和执行功能的损伤都可能反映了背景处理的缺陷。在精神分裂症患者中，背景处理缺陷与背外侧前额叶皮层（DLPFC）的功能障碍有关。方法：我们使用了连续执行任务AX-CPT的变体来检验遗传高危个体的假设，（精神分裂症患者的同胞兄弟姐妹）与社区对照组相比，在背景处理和DLPFC的异常激活方面存在缺陷。精神分裂症患者在AX-CPT上的B-X错误显著更多，表明上下文处理的缺陷。他们还表现出任务相关的超激活在一些大脑区域，包括DLPFC.Conclusions：低效超激活的DLPFC可能是在上下文处理的缺陷，并有助于发展精神分裂症的遗传易感性。
Background: Cognitive dysfunction is a hallmark feature of schizophrenia. In recent years, it has been proposed that impairments in attention, working memory and executive function may all reflect an underlying deficit in context processing. In individuals with schizophrenia, deficits in context processing have been associated with functional impairments of the dorsolateral prefrontal cortex (DLPFC).Methods: We used a variation of the continuous performance task, the AX-CPT, to test the hypothesis that genetic high-risk individuals (full siblings of individuals with schizophrenia) have deficits in context processing and abnormal activation of the DLPFC as compared to community controls.Results: Siblings of individuals with schizophrenia made significantly more B-X errors on the AX-CPT, indicative of a deficit in context processing. They also showed task-related hyper-activation in a number of brain regions, including the DLPFC.Conclusions: Inefficient hyper-activation of the DLPFC may underlie deficits in context processing and contribute to the genetic vulnerability for developing schizophrenia.