Skeletal change in response to altered strain environments: is woven bone a response to elevated strain?
Skeletal change in response to altered strain environments: is woven bone a response to elevated strain?
复制标题
骨骼变化响应改变的应变环境：编织骨是对升高应变的响应吗？
DOI：
10.1016/8756-3282(89)90057-4
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发表时间：
1989
期刊：
影响因子：
4.1
通讯作者：
Radin,EL
中科院分区：
文献类型：
--
作者：
Burr,DB;Schaffler,MB;Yang,KH;Lukoschek,M;Sivaneri,N;Blaha,JD;Radin,EL
研究表明，骨骼结构的几何变化是通过编织骨的形成来响应改变的机械应变而发生的。这项研究的目的是检验以下假设：这些变化部分是手术操作的结果，而不是对应变改变的真正适应性反应。对比格犬进行尺骨截骨术、板固定截骨术或假手术。在手术后 1、3 或 6 个月处死之前测量桡骨的应变。我们的结果支持这样的观点：如果机械挑战足够强烈，编织骨可以是对异常应变环境的正常反应。机械应变升高会导致皮质骨包膜恢复到净形成状态；成人响应机械应变变化的“适应性重塑”可能是建模的一种特殊情况，其中在特定骨骼部位形成之前不需要再吸收。
Studies demonstrate that geometric changes in bone architecture in response to altered mechanical strain occur through the formation of woven bone. The goal of this study was to test the hypothesis that these changes are partly the result of surgical manipulation rather than a true adaptive response to altered strain. Beagle dogs were subjected to either an ulnar osteotomy, an osteotomy with plate fixation, or sham operation. Strains on the radius were measured just prior to sacrifice 1, 3 or 6 months after surgery. Our results support the idea that woven bone can be a normal response to an abnormal strain environment if the mechanical challenge is intense enough; that elevated mechanical strains can cause the endocortical bone envelope to revert to a state of net formation; and that “adaptive remodeling” in adults in response to a change in mechanical strain may be a special case of modeling in which resorption is not required prior to formation at a particular skeletal site.