Cardiac Cachexia: A Well-Known but Challenging Complication of Heart Failure.
Cardiac Cachexia: A Well-Known but Challenging Complication of Heart Failure.
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心脏恶病质：一种众所周知但具有挑战性的心力衰竭并发症。
DOI：
10.2147/cia.s273967
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发表时间：
2020
影响因子：
3.6
通讯作者：
Kałużna-Oleksy M
中科院分区：
文献类型：
--
作者：
Krysztofiak H;Wleklik M;Migaj J;Dudek M;Uchmanowicz I;Lisiak M;Kubielas G;Straburzyńska-Migaj E;Lesiak M;Kałużna-Oleksy M
心衰（Heart failure， HF）是各种心脏疾病的常见并发症，其发病率不断上升。这主要是由于人口老龄化和冠状动脉疾病治疗的改善造成的。随着心衰患者年龄的增长，他们往往会出现合并症，给医疗保健专业人员带来新的问题。肌肉减少症被定义为肌肉质量和功能的丧失，恶病质被定义为由于潜在疾病导致的体重减轻，这是与心力衰竭人群特别相关的肌肉萎缩疾病，但它们大多未被发现。慢性心衰与代谢紊乱并存，有利于恶病质的发生。恶病质，反过来，显著恶化患者的预后和生活质量。恶病质的机制尚不清楚，需要进一步研究。了解其背景对于制定预防和治疗组织损耗的治疗策略至关重要。目前没有针对HF（“心脏恶病质”）的恶病质治疗的具体欧洲指南或推荐疗法。
Heart failure (HF) is a common complication of various cardiac diseases, and its incidence constantly increases. This is caused mainly by aging of populations and improvement in the treatment of coronary artery disease. As HF patients age, they tend to develop comorbidities, creating new problems for health-care professionals. Sarcopenia, defined as the loss of muscle mass and function, and cachexia, defined as weight loss due to an underlying illness, are muscle wasting disorders of particular relevance in the heart failure population, but they go mostly unrecognized. The coexistence of chronic HF and metabolic disorders facilitates the development of cachexia. Cachexia, in turn, significantly worsens a patient’s prognosis and quality of life. The mechanisms underlying cachexia have not been explained yet and require further research. Understanding its background is crucial in the development of treatment strategies to prevent and treat tissue wasting. There are currently no specific European guidelines or recommended therapy for cachexia treatment in HF (“cardiac cachexia”).