Chondrogenesis: Genotypic and phenotypic expression
Chondrogenesis: Genotypic and phenotypic expression
复制标题
软骨形成：基因型和表型表达
DOI：
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发表时间：
1968
影响因子：
5.6
通讯作者：
J. Lash
中科院分区：
文献类型：
--
作者：
J. Lash
越来越明显的是，椎体软骨形成的体外诱导可能不是由于获得了一种新的代谢模式，而是由于已经存在的代谢模式的稳定化。胚胎鸡体节的骨节区域将在体外经历软骨形成，作为对各种刺激的反应，最有效的是胚胎脊索。在刺激之前，体节具有软骨形成所需的所有代谢机制，它们可以合成软骨粘蛋白这一事实证明了这一点。然而，除非在特殊情况下，它们不能积累基质，例如，当它们受到脊索（诱导软骨）等“诱导物”刺激时，或者当它们被允许在适当的培养条件下（例如在富集营养培养基（自发软骨）中）表达其软骨形成倾向时。
It is becoming increasingly evident that the in vitro induction of vertebral chondrogenesis may not be due to the acquisition of a new metabolic pattern, but to the stabilization of one that is already existing. The sclerotome region of embryonic chick somites will undergo chondrogenesis in vitro as a response to various stimuli, the most effective being the embryonic notochord. Before stimulation, the somites have all of the metabolic machinery necessary for chondrogenesis, as evidenced by the fact that they can synthesize chondromucoprotein. They cannot, however, accumulate matrix except under special circumstances, e.g., when they are stimulated by an “inducer” such as the notochord (induced cartilage) or when they are permitted to express their chondrogenic bias under suitable culture conditions, such as in enriched nutrient medium (spontaneous cartilage).