A CASE-CONTROL STUDY OF TRANSIENT GLOBAL AMNESIA
A CASE-CONTROL STUDY OF TRANSIENT GLOBAL AMNESIA
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DOI：
10.1136/jnnp.52.3.320
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发表时间：
1989-03-01
影响因子：
11
通讯作者：
LANDI, G
中科院分区：
文献类型：
--
作者：
GUIDOTTI, M;ANZALONE, N;LANDI, G
为了评估短暂性全面失忆症（TGA）的危险因素和预后，对三组分别受到以下影响的受试者（每组30名）进行了比较：（1）首次TGA;（2）首次短暂性脑缺血发作（TAI）;（3）抑郁性神经症。脑血管病危险因素在TGA和TIA患者中的发生率相似，但在第三组中显著降低。TIA组CT显示低密度病灶多于TGA组。在平均36个月的随访中，5名TGA患者发生了TIA，另外3名TGA复发，但没有发生中风或心肌梗死。在TIA组中，有4人TIA复发，2人中风，2人心肌梗死，而没有人发生TGA发作。第三组的患者在随访期间没有发生任何缺血事件。TGA和TIA患者的危险因素患病率相似，但预后不同，这表明TGA是一种缺血性事件，可能不是由血栓栓塞引发的，而是由不同的可能是血管痉挛的机制引发的。
To evaluate risk factors and prognosis of transient global amnesia (TGA), three groups of 30 subjects each affected respectively by: (1) first-ever TGA; (2) first-ever transient ischaemic attack (TAI); (3) depressive neurosis, were compared. Pevalence of cerebrovascular risk factors was similar in patients with TGA and TIA, but significantly lower in the third group. CT showed more hypodense lesions in TIA patients than in those with TGA. In a mean follow-up of 36 months, five TGA patients experienced a TIA and three others had recurrence of TGA, but none suffered stroke or myocardial infarction. In the TIA group, four had recurrence of TIA, two suffered a stroke and two others a myocardial infarction, whereas none had TGA attacks. None of the patients of the third group had any ischaemic event during follow-up. The similar prevalence of risk factors, but the different prognosis between TGA and TIA patients, suggest that TGA is an ischaemic event, probably not triggered by thromboembolism but by a different, possibly vasospastic, mechanism.