Coffee and Caffeine Improve Insulin Sensitivity and Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
Coffee and Caffeine Improve Insulin Sensitivity and Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
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DOI：
10.1271/bbb.110452
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发表时间：
2011-12-01
影响因子：
1.6
通讯作者：
Horio, Fumihiko
中科院分区：
文献类型：
--
作者：
Matsuda, Yuji;Kobayashi, Misato;Horio, Fumihiko
我们先前已经证明，咖啡和咖啡因改善自发性糖尿病KK-A（y）小鼠的高血糖症。本研究评价了咖啡和咖啡因对高脂饮食诱导的C57 BL/6 J小鼠糖耐量受损的抗糖尿病作用。喂食高脂肪饮食的C57 BL/6 J小鼠被给予常规饮用水（对照组）或2.5倍稀释的咖啡或咖啡因溶液（200 mg/L）17周。与对照组小鼠相比，摄入咖啡或咖啡因可改善葡萄糖耐量、胰岛素敏感性和高胰岛素血症。在咖啡和咖啡因组中，脂肪组织炎症性脂肪细胞因子（MCP-1和IL-6）的mRNA水平以及肝脏脂肪酸合成相关基因的mRNA水平低于对照组。这些结果表明，咖啡和咖啡因通过改善胰岛素敏感性对高脂饮食诱导的糖耐量受损产生了改善作用。这种作用可能部分归因于炎性脂肪细胞因子表达的减少。
We have previously demonstrated that coffee and caffeine ameliorated hyperglycemia in spontaneously diabetic KK-A(y) mice. This present study evaluates the antidiabetic effects of coffee and caffeine on high-fat-diet-induced impaired glucose tolerance in C57BL/6J mice. C57BL/6J mice fed a high-fat diet were given regular drinking water (control group), or a 2.5-fold-diluted coffee or caffeine solution (200 mg/L) for 17 weeks. The ingestion of Coffee or caffeine improved glucose tolerance, insulin sensitivity, and hyperinsulinemia when compared with mice in the control group. The adipose tissue mRNA levels of inflammatory adipocytokines (MCP-1 and IL-6) and the liver mRNA levels of genes related to fatty acid synthesis were lower in the coffee and caffeine groups than those in the control group. These results suggest that coffee and caffeine exerted an ameliorative effect on high-fat-diet-induced impaired glucose tolerance by improving insulin sensitivity. This effect might be attributable in part to the reduction of inflammatory adipocytokine expression.