MULTIPLE ALPHA-KETO ACIDURIA IN MICROTUS-MONTANUS CHRONICALLY INFECTED WITH TRYPANOSOMA-BRUCEI-GAMBIENSE
MULTIPLE ALPHA-KETO ACIDURIA IN MICROTUS-MONTANUS CHRONICALLY INFECTED WITH TRYPANOSOMA-BRUCEI-GAMBIENSE
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DOI：
10.1016/0305-0491(85)90130-0
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发表时间：
1985-01-01
影响因子：
2.2
通讯作者：
SECHELSKI, JB
中科院分区：
文献类型：
--
作者：
HALL, JE;SEED, JR;SECHELSKI, JB
1.布氏冈比亚锥虫单形株慢性感染高山田鼠后，其尿中不仅分泌大量芳香族α-酮酸（苯丙氨酸和4-羟基苯丙氨酸），而且还分泌大量脂肪族α-酮酸（苯丙氨酸和α-酮基谷氨酸）。2.大约在感染中期开始增加酮酸排泄，并且数量一直升高直至死亡。每日酮酸排泄与每日寄生虫血症无关。3.因此，在感染非洲锥虫的实验室动物中存在大的代谢紊乱。多发性α-酮酸尿症可能导致慢性非洲锥虫病的发病机制。
1. Microtus montanus chronically infected with a monomorphic strain of Trypanosama brucei gambiense excreted in urine greatly elevated quantities of not only he aromatic alpha-keto acids, phenylpyruvic and 4-hydroxyphenylpyruvic acids, but also two aliphatic alpha-keto acids, pyruvic and alpha-ketoglutaric acids. 2. Elevated keto acid excretion began approximately midway through infection and quantities remained elevated until death. Daily keto acid excretion did not correlate with daily parasitemia. 3. Thus, a large metabolic disturbance exists in laboratory animals infected with African trypanosomes. The multiple alpha-keto aciduria potentially contributes to the pathogenesis of chronic African trypanosomiasis.