Effect of microstructure on blood cell clogging in blood separators based on capillary action
Effect of microstructure on blood cell clogging in blood separators based on capillary action
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DOI：
10.1007/s00542-008-0663-7
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发表时间：
2009-02-01
影响因子：
2.1
通讯作者：
Lee, Seung S.
中科院分区：
文献类型：
--
作者：
Kim, Duckjong;Yun, Jae Young;Lee, Seung S.
在这项研究中，发生在基于毛细作用的血液分离器中的血细胞堵塞现象进行了仔细研究，并讨论了如何尽量减少堵塞引起的血浆分离速度的降低。在光学透明的玻璃基板上制作了四种不同的血液分离器，以清楚地观察微流控装置中的血浆分离和血细胞堵塞。每个分离实验都由高速摄像机拍摄。使用本研究中提出的理论模型对捕获的图像进行分析，以量化微观结构对血细胞堵塞程度的影响。最后，在分析的基础上，讨论了微型血液分离器的微结构设计准则。
In this study, the blood cell clogging phenomenon occurring in blood separators based on capillary action is carefully investigated and how to minimize the reduction in plasma separation speed caused by clogging is discussed. Four different blood separators are fabricated on optically transparent glass substrates to clearly observe the blood plasma separation and the blood cell clogging in the microfluidic devices. Each separation experiment is captured by a high-speed video camera. The captured images are analyzed using a theoretical model proposed in this study to quantify the effect of the microstructure on the degree of blood cell clogging. Finally, design guidelines for the microstructure of the micro blood separator are discussed based on the analysis.