Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections
Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections
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DOI：
10.1086/515635
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发表时间：
1998-08-01
影响因子：
6.4
通讯作者：
Stamm, WE
中科院分区：
文献类型：
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作者：
Gupta, K;Stapleton, AE;Stamm, WE
反复尿路感染(UTI)的妇女经常表现出持续的阴道定植，感染了大肠杆菌。由于产生过氧化氢的乳杆菌菌株抑制了大肠杆菌的生长，这些菌株的缺乏可能容易导致大肠杆菌的定植和尿路感染。为了验证这一假设，从140名女性，65名复发性尿路感染患者(病例组)和75名非复发性尿路感染患者(对照组)进行了阴道内培养。病例组患者阴道内大肠埃希菌定植的发生率显著高于对照组(35%比11%；P
Women with recurrent urinary tract infection (UTI) often demonstrate persistent vaginal colonization with Escherichia coli. Since strains of lactobacilli that produce hydrogen peroxide inhibit the growth of E. coli, the absence of these strains may predispose to E. coli colonization and to UTI. To test this hypothesis, vaginal introital cultures were obtained from 140 women, 65 with recurrent UTI (case-patients) and 75 without (controls). Vaginal E. coli colonization was significantly more frequent in case-patients than controls (35% vs. 11%; P