MICROSATELLITE MAPPING OF A GENE AFFECTING HORN DEVELOPMENT IN BOS-TAURUS
MICROSATELLITE MAPPING OF A GENE AFFECTING HORN DEVELOPMENT IN BOS-TAURUS
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DOI：
10.1038/ng0693-206
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发表时间：
1993-06-01
期刊：
影响因子：
30.8
通讯作者：
HETZEL, J
中科院分区：
文献类型：
--
作者：
GEORGES, M;DRINKWATER, R;HETZEL, J
普通牛有无角被认为是受常染色体无角基因座的遗传控制，其特征是两个等位基因：P对p显性，并导致无角或无角表型。我们已经证明了无角位点和两个微卫星标记，GMPOLL-1和GMPOLL-2之间的遗传连锁，并已分配相应的连锁群牛1号染色体。这证实了假设的无角基因座和假设的遗传模式的存在。它将允许在育种计划中对无角性状进行标记辅助选择，并且是对已经经历自然和人工选择的基因进行定位克隆和分子研究的第一步。
The presence or absence of horns in Bos taurus is thought to be under the genetic control of the autosomal polled locus, characterized by two alleles: P dominant over p, and causing the polled or hornless phenotype. We have demonstrated genetic linkage between the polled locus and two microsatellite markers, GMPOLL-1 and GMPOLL-2, and have assigned the corresponding linkage group to bovine chromosome 1. This confirms the existence of the postulated polled locus and the hypothesized inheritance pattern. It will allow marker assisted selection for the polledness trait in breeding programs and is a first step towards positional cloning and molecular study of a gene that has been subjected to both natural and artificial selection.