Surface markers and prognostic factors in acute lymphoblastic leukemia.
Surface markers and prognostic factors in acute lymphoblastic leukemia.
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急性淋巴细胞白血病的表面标志物和预后因素。
DOI：
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发表时间：
1976
影响因子：
158.5
通讯作者：
Beatrice C. Lampkin
中科院分区：
文献类型：
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作者：
Ichiro Tsukimoto;K. Y. Wong;Beatrice C. Lampkin
我们对37例急性淋巴细胞白血病患者的淋巴母细胞表面标志进行了研究。用绵羊红细胞（E红细胞）的自发玫瑰花结形成鉴定了T细胞，表面免疫球蛋白的存在鉴定了B细胞。8例患者有T标记淋巴母细胞; 28例无标记（空淋巴母细胞），1例患者有B标记淋巴母细胞。8例T标记急性淋巴细胞白血病患者有大量的白血病浸润，经常是纵隔肿块，预后差。T标记淋巴母细胞具有弱或阴性的高碘酸希夫反应，对同种异体淋巴细胞的抗原刺激性很低。T标记淋巴母细胞和一些传统的不良风险因素的关联似乎是可靠的预测预后不良。
We investigated the surface markers on lymphoblasts from 37 patients with acute lymphoblastic leukemia. Spontaneous rosette formation with sheep erythrocytes (E rosettes) identified T cells and the presence of surface immunoglobulin identified B cells. Eight patients had T-marker lymphoblasts; 28 had no markers (null lymphoblasts), and one patient had B-marker lymphoblasts. The eight patients with T-marker acute lymphoblastic leukemia had massive leukemic infiltration, frequently a mediastinal mass, and a poor prognosis. The T-marker lymphoblasts had a weak or negative periodic acid-Schiff reaction and a very low antigenic stimulation to allogeneic lymphocytes. The association of T-marker lymphoblasts and some of the conventional poor-risk factors appears to be reliable in predicting a poor prognosis.