Prevalence of HIV-1-infection in dialysis units in Spain and potential candidates for renal transplantation:: Results of a Spanish survey
Prevalence of HIV-1-infection in dialysis units in Spain and potential candidates for renal transplantation:: Results of a Spanish survey
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DOI：
10.1157/13076172
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发表时间：
2005-06-01
影响因子：
2.5
通讯作者：
Miró, JM
中科院分区：
文献类型：
--
作者：
Barril, G;Trullás, JC;Miró, JM
导论. HIV感染和终末期肾病（ESRD）患者的生存率在过去几年中有所提高。HIV感染并不被认为是肾移植的矛盾，但在HIV感染者中进行肾移植的经验很少。目前还没有关于西班牙肾脏替代治疗（RRT）患者HIV感染的流行情况的信息。2004年在西班牙透析单位进行了一项调查。目的是研究西班牙RRT患者中HIV感染的流行率和特征。我们还想知道他们中有多少人符合西班牙的标准，被列入肾移植等待名单。4，962例接受RRT的患者中，HIV患病率为1.15%（95%CI 0.85-1.45），大多数患者接受血液透析，腹膜透析较少见。HIV感染最常见的危险因素是注射毒品（58%）。终末期肾病最常见的病因是肾小球肾炎（44%）。RRT下的中位时间为46个月。同时感染丙型肝炎（60%）和B型肝炎（7%），34%的患者有艾滋病史。86%的人接受了HAART治疗。中位CD 4细胞计数为333个细胞/μ l，68%的病毒载量检测不到。在完成临床问卷的40例患者中，9例（22.5%）符合西班牙肾移植标准。在西班牙接受RRT的患者中，艾滋病毒感染率为1.15%（0.85%-1.45%），其中22.5%的患者符合西班牙的肾移植等候名单标准。
INTRODUCTION. Patients with HIV infection and end-stage renal disease (ESRD) have improved their survival in the last few years. HIV infection is not considered a contradiction for renal transplantation, but little experience exists in renal transplantation in HIV infected individuals. There is no information about the prevalence of HIV infection in Spanish patients under renal replacement therapies (RRT).METHODS. A survey was performed in Spanish dialysis units during 2004. The objective was to study the prevalence and characteristics of HIV infection in patients under RRT in Spain. We also aimed to know how many of them met the Spanish criteria to be included on the renal transplantation waiting list.RESULTS. HIV prevalence was 1.15% (95%CI 0.85-1.45) of 4,962 patients who were under RRT, mostly under hemodialysis and, less commonly, peritoneal dialysis. The most frequent risk factor for HIV infection was parenteral drug use (58%). The most common causes of ESRD were glomerulonephritis (44%). The median time under RRT was 46 months. Coinfections with hepatitis C (60%) and B (7%) were found. Thirty-four percent of patients had a history of aids-defining events. Eighty-six percent were under HAART. The median CD4 cell count was 333 cells/mu l and the viral load was undetectable in 68%. Of 40 patients with a completed clinical questionnaire, 9 (22.5%) met the Spanish criteria for renal transplantation.CONCLUSION. HIV prevalence in patients under RRT in Spain is 1.15% (0.85%-1.45%) and 22.5% percent of these patients met the Spanish criteria to be included on a renal transplantation waiting list.