THE EFFECT OF ANGIOTENSIN-II ON INVIVO ALBUMIN TRANSPORT IN NORMAL RABBIT AORTIC TISSUE
THE EFFECT OF ANGIOTENSIN-II ON INVIVO ALBUMIN TRANSPORT IN NORMAL RABBIT AORTIC TISSUE
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DOI：
10.1016/0021-9150(82)90005-3
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发表时间：
1982-01-01
期刊：
影响因子：
5.3
通讯作者：
LEES, RS
中科院分区：
文献类型：
--
作者：
FEIG, LA;PEPPAS, NA;LEES, RS
血管紧张素II和其他血管活性胺可能对动脉壁的通透性有直接影响。研究了静脉注射[125]白蛋白后，血管紧张素II对家兔体内白蛋白转运穿过主动脉壁的影响。通过连续切片技术测量血管紧张素或生理盐水输注25分钟期间产生的125 I标记的白蛋白在主动脉内膜和中膜中的浓度分布。通过主动脉壁的标记白蛋白的摄取依赖于位置，并增加从降胸到弓。血管紧张素输注增加白蛋白的摄取在该地区的主动脉近端的第一对肋间动脉和放大的位置依赖性。血管紧张素输注没有改变肋间动脉之间的降主动脉中白蛋白的摄取。与血管紧张素输注相关的动脉血压升高在产生上述摄取模式方面并不重要。[The血管紧张素II可能参与动脉粥样硬化的讨论。
Angiotensin II and other vasoactive amines may have a direct effect on the permeability of the arterial wall. The effect of angiotensin II in vivo albumin transport across the aortic wall in rabbits following i.v. injection of [125]albumin was investigated. Transmural concentration profiles of 125I-labeled albumin across the intima and media of the aorta, generated during 25 min of either angiotensin or saline infusion, were measured by a serial-sectioning technique. The uptake of labeled albumin through the aortic wall was dependent on position and increased from the descending thoracic up to the arch. Angiotensin infusion increased albumin uptake in the region of the aorta proximal to the 1st pair of intercostal arteries and magnified the position dependence. Angiotensin infusion did not change the uptake of albumin in the descending thoracic aorta between intercostal arteries. The arterial blood pressure elevation associated with angiotensin infusion was not of prime importance in producing the uptake patterns described above. [The possible involvement of angiotensin II in atherosclerosis is discussed.].