Influence of early or late dietary restriction on life span and immunological parameters in MRL/Mp-lpr/lpr mice.
Influence of early or late dietary restriction on life span and immunological parameters in MRL/Mp-lpr/lpr mice.
复制标题
早期或晚期饮食限制对 MRL/Mp-lpr/lpr 小鼠寿命和免疫学参数的影响。
DOI：
10.1073/pnas.81.18.5831
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发表时间：
1984
影响因子：
11.1
通讯作者：
Good,RA
中科院分区：
文献类型：
--
作者：
Kubo,C;Day,NK;Good,RA
MRL/Mp-lpr/lpr （MRL/l）品系小鼠在保持维生素和矿物质摄取量不变的情况下，减少食物摄取量可使（NZB X NZW）F1 （B/W）小鼠的寿命增加一倍甚至两倍。限制食物摄入可以大大延长寿命。当饮食限制在以后的生活中施加时，也会出现这种影响。饮食限制抑制了淋巴增生性疾病的发展，并大大减少了胸腺、淋巴结和脾脏的细胞数量。它还能延缓肾小球肾炎的发展并维持一定的免疫反应。从6周开始，低热量饮食的小鼠对植物血凝素、美洲商陆有丝分裂原或异体脾细胞的增殖反应保持不变。在12周时强制节食的影响比之前的限制要小。这些饮食影响并不会抑制抗dna抗体或循环免疫复合物的形成。MRL/l小鼠白细胞介素2的产生明显极低，饮食限制增加了淋巴结细胞而不是脾脏细胞产生这种免疫调节剂的能力。
Reduced food intake doubles and even triples the life span of (NZB X NZW)F1 (B/W) mice and greatly influences of food intake while keeping vitamin and mineral intake constant in mice of the MRL/Mp-lpr/lpr (MRL/l) strain. Restriction of food intake greatly prolongs life. This influence also was seen when dietary restriction was imposed later in life. Dietary restriction inhibited development of lymphoproliferative disease and greatly decreased the numbers of cells in thymus, lymph nodes, and spleen. It also delayed development of glomerulonephritis and maintained certain immunological responses. Proliferative responses to phytohemagglutinin, pokeweed mitogen, or allogeneic spleen cells were maintained in the mice fed a low-calorie diet from 6 wk. Imposing diet at 12 wk had a lesser influence than earlier restriction. These dietary influences did not depress formation of anti-DNA antibodies or circulating immunocomplexes. MRL/l mice show an apparently extremely low production of interleukin 2, and dietary restriction increased the capacity of lymph node cells but not spleen cells to produce this immunomodulator.