TAXOL CAUSES PERMANENT LARGE FIBER PERIPHERAL-NERVE DYSFUNCTION - A LESSON FOR PREVENTATIVE STRATEGIES
TAXOL CAUSES PERMANENT LARGE FIBER PERIPHERAL-NERVE DYSFUNCTION - A LESSON FOR PREVENTATIVE STRATEGIES
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DOI：
10.1007/bf01324696
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发表时间：
1993-01-01
影响因子：
3.9
通讯作者：
SCHAUMBURG, HH
中科院分区：
文献类型：
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作者：
KAPLAN, JG;EINZIG, AI;SCHAUMBURG, HH
抗肿瘤剂紫杉醇会引起感觉神经病变，这可能会限制其剂量[1]。停止治疗后，神经病变的症状通常会改善[1]，但没有长期神经系统影响的报道。实验动物研究表明紫杉醇主要导致小纤维功能障碍。我们的经验表明，紫杉醇神经病还会影响人类的大轴突，并在高剂量给药时导致持续性功能障碍。
The anti-neoplastic agent taxol causes a sensory neuropathy which may limit its dose [1]. Symptomatic improvement of neuropathy is usual after cessation of therapy [1], but there are no reports of long term neurological effects. Experimental animal studies suggest that taxol causes predominant small fiber dysfunction. Our experience suggests that taxol neuropathy additionally affects large axons in humans and results in persistent dysfunction when given in high doses.