Effects of oral administration of caffeine and D-ribose on mental fatigue
Effects of oral administration of caffeine and D-ribose on mental fatigue
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DOI：
10.1016/j.nut.2007.12.002
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发表时间：
2008-03-01
期刊：
影响因子：
4.4
通讯作者：
Watanabe, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Ataka, Suzuka;Tanaka, Masaaki;Watanabe, Yasuyoshi
目的：我们研究了两种不同的候选抗疲劳物质，咖啡因和D-核糖，对精神fatigue.Methods：在一个双盲，安慰剂对照，三向交叉设计，17名健康志愿者被随机口服咖啡因（200 mg/d），D-核糖（2000 mg/d），或安慰剂8天。作为疲劳诱导的心理任务，受试者进行了30分钟的内田-克雷佩廷心理诊断测试和30分钟的先进trail-making测试，在四个occasions.Results：任务期间，咖啡因组的任务绩效优于安慰剂组。然而，在疲劳诱导任务后，虽然主观感觉疲劳，动机，或嗜睡没有显着差异，血浆支链氨基酸水平的咖啡因组低于安慰剂组。行政D-核糖had no effect.Conclusion：由于血浆支链氨基酸水平下降的精神疲劳，这些结果表明，行政咖啡因通过增强中枢神经系统的活动，而不增加疲劳的感觉，提高了任务的性能。然而，支链氨基酸水平的进一步下降表明，咖啡因可能比安慰剂更容易引起更深的疲劳。不幸的是，我们的研究设计之后的研究表明，D-核糖的剂量需要高于我们使用的剂量才能看到临床效果，因此无法从本研究中得出关于D-核糖疗效的结论。(C)2008年爱思唯尔公司All rights reserved.
Objective: We examined the effects of administering two different candidate antifatigue substances, caffeine and D-ribose, on mental fatigue.Methods: In a double-blinded, placebo-controlled, three-way crossover design, 17 healthy volunteers were randomized to oral caffeine (200 mg/d), D-ribose (2000 mg/d), or placebo for 8 d. As fatigue-inducing mental tasks, subjects performed a 30-min Uchida-Kraepetin psychodiagnostic test and a 30-min advanced trail-making test on four occasions.Results: During the tasks, the task performance of the caffeine group was better than that of the placebo group. However, after the fatigue-inducing tasks, although subjective perception of fatigue, motivation, or sleepiness was not significantly different, plasma branched-chain amino acid levels in the caffeine group were lower than those of the placebo group. Administration of D-ribose had no effect.Conclusion: Because plasma branched-chain amino acid levels are decreased by mental fatigue, these results suggest that administration of caffeine improved task performance through the enhancement of central nervous system activity without increasing the sensation of fatigue. However, further decreases in branched-chain amino acid levels indicate that caffeine might promote deeper fatigue than placebo. Unfortunately, research subsequent to our study design has shown that D-ribose dosing higher than we used is needed to see a clinical effect and therefore no conclusions can be made from this study as to the efficacy of D-ribose. (C) 2008 Elsevier Inc. All rights reserved.