Midlife personality and risk of Alzheimer disease and distress A 38-year follow-up
Midlife personality and risk of Alzheimer disease and distress A 38-year follow-up
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DOI：
10.1212/wnl.0000000000000907
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发表时间：
2014-10-21
期刊：
影响因子：
9.9
通讯作者：
Skoog, Ingmar
中科院分区：
文献类型：
--
作者：
Johansson, Lena;Guo, Xinxin;Skoog, Ingmar
目的：研究跟踪了 38 年的女性样本中中年神经质和外向性以及晚年痴呆和长期困扰之间的关系。方法：1968 年对 800 名年龄在 38 至 54 岁的女性进行了人口抽样调查，并于 1974 年、1980 年、1992 年、2000 年和 2005 年进行了后续检查。 神经质和外向性在基线时使用艾森克人格量表进行评估。根据每个研究波次的标准化问题来测量痛苦。根据 DSM-III-R 标准，根据神经精神检查、知情者访谈、医院记录和登记数据的信息，诊断痴呆症。结果：在 38 年的随访中，153 名女性患上了痴呆症；其中 104 人被诊断为阿尔茨海默病 (AD) 痴呆。中年时期神经质程度较高与 AD 痴呆风险增加和 38 年来长期困扰有关。在调整长期困扰后，神经质与 AD 痴呆之间的关联减弱。外向性与较低程度的长期困扰相关，但对 AD 痴呆没有影响。当两个人格维度结合起来时，高神经质/低外向性显示 AD 痴呆的风险最高。结论：我们的研究表明，中年神经质与 AD 痴呆风险增加相关，而痛苦介导了这种关联。该结果具有临床意义，因为确定了一组有 AD 痴呆风险的女性。
Objective: To study the association between midlife neuroticism and extraversion and development of late-life dementia and long-standing distress in a sample of women followed for 38 years.Methods: A population-based sample of 800 women, aged 38 to 54 years, was examined in 1968, with subsequent examinations in 1974, 1980, 1992, 2000, and 2005. Neuroticism and extraversion were assessed using the Eysenck Personality Inventory at baseline. Distress was measured according to a standardized question at each study wave. Dementia was diagnosed according to DSM-III-R criteria based on information from neuropsychiatric examinations, informant interviews, hospital records, and registry data.Results: During the 38-year follow-up, 153 women developed dementia; Alzheimer disease (AD) dementia was diagnosed in 104 of these. A higher degree of neuroticism in midlife was associated with increased risk of AD dementia and long-standing distress over 38 years. The association between neuroticism and AD dementia diminished after adjusting for long-standing distress. Extraversion was associated with a lower degree of long-standing distress, but had no impact on AD dementia. When the 2 personality dimensions were combined, high neuroticism/low extraversion showed the highest risk of AD dementia.Conclusions: Our study suggests that midlife neuroticism is associated with increased risk of AD dementia, and that distress mediates this association. The results have clinical implications because a group of women at risk of AD dementia is identified.