Involvement of amygdaloid corticosterone in altered visceral and somatic sensation
Involvement of amygdaloid corticosterone in altered visceral and somatic sensation
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DOI：
10.1016/j.bbr.2007.03.031
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发表时间：
2007-07-19
影响因子：
2.7
通讯作者：
Greenwood-Van Meerveld, Beverley
中科院分区：
文献类型：
--
作者：
Myers, Brent;Dittmeyer, Kale;Greenwood-Van Meerveld, Beverley
在杏仁核植入立体定位皮质酮（CORT）的大鼠中，使用对热和机械刺激的行为反应来检查躯体敏感性。这些动物先前已显示出焦虑样行为与结肠高敏感性相结合;在这项研究中，CORT不仅诱导内脏高敏感性，还诱导躯体高敏感性。这些发现表明，调制杏仁核与CORT的结果在一个普遍的感觉阈值下降，通过下行神经元通路。(c)2007 Elsevier B. V.保留所有权利。
Behavioral responses to thermal and mechanical stimuli were used to examine somatic sensitivity in rats with stereotaxic corticosterone (CORT) implants on the amygdala. These animals have previously been shown to display anxiety-like behavior coupled with colonic hypersensitivity; in this study, CORT induced not only visceral hypersensitivity but also somatic hypersensitivity. These findings suggest that modulation of the amygdala with CORT results in a generalized decrease in sensory thresholds via descending neuronal pathways. (c) 2007 Elsevier B.V. All rights reserved.