Incidence of Diabetes and Prediabetes and Predictors of Progression Among Asian Indians: 10-Year Follow-up of the Chennai Urban Rural Epidemiology Study (CURES)
Incidence of Diabetes and Prediabetes and Predictors of Progression Among Asian Indians: 10-Year Follow-up of the Chennai Urban Rural Epidemiology Study (CURES)
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DOI：
10.2337/dc14-2814
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发表时间：
2015-08-01
期刊：
影响因子：
16.2
通讯作者：
Mohan, Viswanathan
中科院分区：
文献类型：
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作者：
Anjana, Ranjit Mohan;Rani, Coimbatore Subramanian Shanthi;Mohan, Viswanathan
关于亚洲印度人糖尿病和糖尿病前期（糖尿病）的发病率数据很少。本文介绍了糖尿病和糖尿病前期的发病率和进展的预测因素在人口为基础的亚洲印度cohol.RESEARCH设计和METHODS数据进展为糖尿病和糖尿病前期从1,376个人，一个子集的2,207金奈城市农村流行病学研究（治愈）队列（3期）与正常葡萄糖耐量（NGT）或糖尿病前期在基线，中位随访时间为9.1年（11，629人-年）。在随访期间，534人死亡，1，077名NGT患者和299名糖尿病前期患者在基线时进行了10年随访研究。糖尿病和前驱糖尿病的诊断是基于美国糖尿病协会的标准。采用考克斯比例风险模型计算发病率并估计进展为糖尿病前期和/或糖尿病的预测因子。糖尿病、糖尿病前期和“任何疾病”的发病率分别为22.2、29.5和51.7/1000人-年。在NGT患者中，19.4%转化为糖尿病，25.7%转化为前驱糖尿病，总转化率为45.1%。在糖尿病前期患者中，58.9%转化为糖尿病。预测进展到dysbylism是年龄增长，糖尿病家族史，2小时血糖，糖化血红蛋白（HbA（1c）），低HDL胆固醇，和身体inactivity.CONCLUSIONSAsian印度人有一个糖尿病的发病率最高，从normoalbumin到dysbylism的快速转换。公共卫生干预措施应针对可改变的风险因素，以减缓糖尿病在这一人群中的流行。
OBJECTIVEThere are few data on the incidence rates of diabetes and prediabetes (dysglycemia) in Asian Indians. This article presents the incidence of diabetes and prediabetes and the predictors of progression in a population-based Asian Indian cohort.RESEARCH DESIGN AND METHODSData on progression to diabetes and prediabetes from 1,376 individuals, a subset of 2,207 of the Chennai Urban Rural Epidemiology Study (CURES) cohort (phase 3) with normal glucose tolerance (NGT) or prediabetes at baseline, who were followed for a median of 9.1 years (11,629 person-years), are presented. During follow-up, 534 died and 1,077 with NGT and 299 with prediabetes at baseline were reinvestigated in a 10-year follow-up study. Diabetes and prediabetes were diagnosed based on the American Diabetes Association criteria. Incidence rates were calculated and predictors of progression to prediabetes and/or diabetes were estimated using the Cox proportional hazards model.RESULTSThe incidence rates of diabetes, prediabetes, and "any dysglycemia" were 22.2, 29.5, and 51.7 per 1,000 person-years, respectively. Among those with NGT, 19.4% converted to diabetes and 25.7% to prediabetes, giving an overall conversion rate to dysglycemia of 45.1%. Among those with prediabetes, 58.9% converted to diabetes. Predictors of progression to dysglycemia were advancing age, family history of diabetes, 2-h plasma glucose, glycated hemoglobin (HbA(1c)), low HDL cholesterol, and physical inactivity.CONCLUSIONSAsian Indians have one of the highest incidence rates of diabetes, with rapid conversion from normoglycemia to dysglycemia. Public health interventions should target modifiable risk factors to slow down the diabetes epidemic in this population.