The effect of zinc supplementation on pregnancy outcome.
The effect of zinc supplementation on pregnancy outcome.
复制标题
DOI：
10.1001/jama.1995.03530060037030
复制
发表时间：
1995-08
期刊：
影响因子：
--
通讯作者：
R L Goldenberg;Tsunenobu Tamura;Y. Neggers;R. Copper;K. Johnston;M. Dubard;J. Hauth
中科院分区：
文献类型：
--
作者：
R L Goldenberg;Tsunenobu Tamura;Y. Neggers;R. Copper;K. Johnston;M. Dubard;J. Hauth
目的：评价孕期补锌是否与新生儿出生体重增加有关。设计：随机双盲安慰剂对照试验。背景：阿拉巴马大学伯明翰分校的门诊和分娩服务。患者：580名医学上贫困但其他方面健康的非裔美国孕妇，在产前护理登记时血浆锌水平低于中位数，随机分布于19周孕龄。根据人群中位数体重指数26 kg/m2将女性细分为两组进行进一步分析。干预措施产前服用不含锌的复合维生素/矿物质片的妇女被随机分为每天服用25毫克锌或安慰剂直到分娩。主要结果测量出生体重，出生时胎龄，出生时头围。结果：在所有女性中，锌补充剂组婴儿的出生体重（126 g, P = .03）和头围（0.4 cm, P = .02）均显著高于安慰剂组婴儿。在体重指数小于26 kg/m2的妇女中，补充锌与婴儿出生体重增加248 g （P = 0.005）和婴儿头围增加0.7 cm （P = 0.007）相关。补锌组血浆锌浓度显著高于对照组。结论：妊娠早期血浆锌浓度相对较低的妇女每日补锌与较大的婴儿出生体重和头围相关，这种影响主要发生在体重指数小于26 kg/m2的妇女中。
OBJECTIVE To evaluate whether zinc supplementation during pregnancy is associated with an increase in birth weight. DESIGN A randomized double-blind placebo-controlled trial. SETTING Outpatient clinic and delivery service at the University of Alabama at Birmingham. PATIENTS Five hundred eighty medically indigent but otherwise healthy African-American pregnant women with plasma zinc levels below the median at enrollment in prenatal care, randomized at 19 weeks' gestational age. Women were subdivided by the population median body mass index of 26 kg/m2 into two groups for additional analyses. INTERVENTION Women who were taking a non-zinc-containing prenatal multivitamin/mineral tablet were randomized to receive either a daily dose of 25 mg of zinc or a placebo until delivery. MAIN OUTCOME MEASURES Birth weight, gestational age at birth, and head circumference at birth. RESULTS In all women, infants in the zinc supplement group had a significantly greater birth weight (126 g, P = .03) and head circumference (0.4 cm, P = .02) than infants in the placebo group. In women with a body mass index less than 26 kg/m2, zinc supplementation was associated with a 248-g higher infant birth weight (P = .005) and a 0.7-cm larger infant head circumference (P = .007). Plasma zinc concentrations were significantly higher in the zinc supplement group. CONCLUSIONS Daily zinc supplementation in women with relatively low plasma zinc concentrations in early pregnancy is associated with greater infant birth weights and head circumferences, with the effect occurring predominantly in women with a body mass index less than 26 kg/m2.