Physiological roles for ecto-5'-nucleotidase (CD73).
Physiological roles for ecto-5'-nucleotidase (CD73).
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DOI：
10.1007/s11302-005-5302-5
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发表时间：
2006-06
影响因子：
3.5
通讯作者：
Thompson, Linda F
中科院分区：
文献类型：
--
作者：
Colgan, Sean P;Eltzschig, Holger K;Eckle, Tobias;Thompson, Linda F
核苷酸和核苷几乎影响生理学和病理生理学的各个方面。细胞外核苷酸通过一系列胞外核苷酸酶调节磷酸水解代谢。从腺苷5 '-单磷酸形成胞外腺苷主要通过胞外-5'-核苷酸酶（CD 73）完成，这是一种在多种细胞类型表面发现的糖基磷脂酰肌醇连接的膜蛋白。最近在体内研究牵连CD 73在一些组织保护机制提供了新的见解，其调节和功能，并产生了相当大的兴趣。在这里，我们回顾CD 73对细胞和组织应激反应的贡献，特别强调调节CD 73表达和功能的生理反应，以及利用CD 73缺陷动物的新发现。
Nucleotides and nucleosides influence nearly every aspect of physiology and pathophysiology. Extracellular nucleotides are metabolized through regulated phosphohydrolysis by a series of ecto-nucleotidases. The formation of extracellular adenosine from adenosine 5’-monophosphate is accomplished primarily through ecto-5’-nucleotidase (CD73), a glycosyl phosphatidylinositol-linked membrane protein found on the surface of a variety of cell types. Recent in vivo studies implicating CD73 in a number of tissue protective mechanisms have provided new insight into its regulation and function and have generated considerable interest. Here, we review contributions of CD73 to cell and tissue stress responses, with a particular emphasis on physiologic responses to regulated CD73 expression and function, as well as new findings utilizing Cd73-deficient animals.