Chronic Prostate Inflammation is Associated with Severity and Progression of Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms and Risk of Acute Urinary Retention
Chronic Prostate Inflammation is Associated with Severity and Progression of Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms and Risk of Acute Urinary Retention
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DOI：
10.1016/j.juro.2016.06.090
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发表时间：
2016-11-01
影响因子：
6.6
通讯作者：
Moreira, Daniel M.
中科院分区：
文献类型：
--
作者：
Nickel, J. Curtis;Roehrborn, Claus G.;Moreira, Daniel M.
目的：我们在REDUCE研究中评估了随机接受安慰剂的男性中组织学前列腺炎症与良性前列腺增生/下尿路症状的发生和进展之间的关系。（通过度他雄胺减少前列腺癌事件）的研究。材料和方法：基线活检中检测到的急性和慢性炎症与良性前列腺增生相关参数的相关性，包括I-PSS（国际前列腺症状评分）和前列腺体积，在4年期间的多个时间点，在随机分配到安慰剂组的男性中，在REDUCE前列腺癌预防研究中，用Student t检验进行分析。采用单变量和多变量考克斯模型分析炎症与新发良性前列腺增生/下尿路症状和已有良性前列腺增生/下尿路症状患者中良性前列腺增生进展的相关性。在研究的4,109名男性中，641名（15.6%）和3,216名（78.3%）的基线阴性活检中观察到急性和慢性炎症。慢性而非急性炎症与略高的基线I-PSS（差异0.6，p = 0.001）和较大的前列腺体积（差异3.2 cc，p
Purpose: We evaluated associations between histological prostate inflammation, and the development and progression of benign prostatic hyperplasia/lower urinary tract symptoms in men randomized to placebo in the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) study in a 4-year period.Materials and Methods: The association of acute and chronic inflammation detected on baseline biopsies and benign prostatic hyperplasia related parameters, including I-PSS (International Prostate Symptom Score) and prostate volume, at multiple time points during 4 years in men randomized to placebo enrolled in the REDUCE prostate cancer prevention study was analyzed with the Student t-test. The association of inflammation with newly developed benign prostatic hyperplasia/lower urinary tract symptoms and benign prostatic hyperplasia progression in patients with existing benign prostatic hyperplasia/lower urinary tract symptoms was analyzed with univariable and multivariable Cox models.Results: Acute and chronic inflammation was seen in baseline negative biopsies of 641 (15.6%) and 3,216 (78.3%) of the 4,109 men in the study. Chronic but not acute inflammation was associated with slightly higher baseline I-PSS (0.6 difference, p = 0.001) and larger prostate volume (3.2 cc difference, p