CELL-AUTONOMOUS DETERMINATION OF CELL-TYPE CHOICE IN DICTYOSTELIUM DEVELOPMENT BY CELL-CYCLE PHASE
CELL-AUTONOMOUS DETERMINATION OF CELL-TYPE CHOICE IN DICTYOSTELIUM DEVELOPMENT BY CELL-CYCLE PHASE
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DOI：
10.1126/science.3039657
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发表时间：
1987-08-14
期刊：
影响因子：
56.9
通讯作者：
FIRTEL, RA
中科院分区：
文献类型：
--
作者：
GOMER, RH;FIRTEL, RA
单个细胞的发育命运已经在一个允许D.盘状细胞在没有聚集的情况下分化。结果表明，单个变形虫分化为前孢子或前柄细胞的倾向是通过细胞自主机制发生的，这取决于细胞在发育开始时在细胞周期中的位置。细胞在. apprx.一个半小时前和.apprx.诱导分化的饥饿40分钟后成为前柄细胞，而在其他时间分裂的细胞成为前孢子细胞。这些结果表明机制，通过该机制实现了聚集体内两种细胞类型的初始比例。
The developmental fate of individual cells has been examined in a system that allows D. discoideum cells to diferentiate in the absence of aggregation. The results show that the propensity of single amoebae to differentiate into either prespore or prestalk cells occurs by a cell-autonomous mechanism dependent on the cell''s position in the cell cycle at the initiation of development. Cells that divide between .apprx. 1 1/2 hours before and .apprx. 40 minutes after the differentiation-inducing starvation become prestalk, whereas cells dividing at other times become prespore cells. These results suggest mechanisms by which an initial proportioning of the two cell types within the aggregate is achieved.