Clinical implications of p57 KIP2 expression in breast cancer.
Clinical implications of p57 KIP2 expression in breast cancer.
复制标题
p57 KIP2 表达在乳腺癌中的临床意义。
DOI：
10.7314/apjcp.2012.13.10.5033
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Bo Chen
中科院分区：
文献类型：
--
作者：
Xiaoyin Xu;Wenqian Wang;Lei Zhang;Yi;Miao Tang;Nan Jiang;Shouliang Cai;Liang Wei;F. Jin;Bo Chen
目的
探讨p57 KIP 2蛋白在浸润性乳腺癌中的表达与预后及其他临床病理参数的关系。
方法
应用免疫组化方法检测89例浸润性乳腺癌和20例正常乳腺组织中p57 KIP 2的表达，并将结果用SPSS软件进行统计学分析。16.0）。
结果
p57 KIP 2蛋白在浸润性乳腺癌和癌旁正常组织中的阳性表达率分别为30.3%（27/89）和65%（13/20）。p57 KIP 2阴性表达组术后远处转移率（37.9%）明显高于p57 KIP 2阳性表达组（14.8%）（P = 0.01）。DFS分析显示，p57 KIP 2-/C-erbB-2μ肿瘤的术后远处转移率也显著高于其他组（66.7% vs. 29.2%; P = 0.007），p57 KIP 2-/p53μ肿瘤也是如此（64.3% vs. 22.7%; P = 0.001）。生存分析显示，p57 KIP 2与乳腺癌特异性总体生存率相关（P = 0.045，对数秩检验）。亚组分析表明，p57 KIP 2-/C-erbB-2μ肿瘤患者的术后生存率明显低于p57 KIP 2- /C-erbB-2-或其他肿瘤患者（P = 0.006，log-rank检验）。与p57 KIP 2-/p53-或其他肿瘤相比，p57 KIP 2-/p53μ肿瘤的术后生存率显著更差（P = 0.001，对数秩检验）。考克斯回归分析显示p57 KIP 2是乳腺癌的非独立预后因素（P = 0.303）。
结论
p57 KIP 2在浸润性乳腺癌中表达较低，与乳腺癌患者的总生存率和无病生存率相关，但其对乳腺癌的预后影响不独立。因此，p57 KIP 2/p53和p57 KIP 2/C-erbB-2之间的联系可能为乳腺癌提供生物标志物。
OBJECTIVE
To study the relationship between expression of p57KIP2 and prognosis and other clinicopathological parameters in invasive breast cancers.
METHODS
We assessed the expression of p57KIP2 in 89 cases of invasive breast cancer and 20 cases of normal breast tissue by immunohistochemical methods and analyzed the results with SPSS software (ver. 16.0).
RESULT
The positive expression rates of p57KIP2 protein in the invasive breast cancers and surrounding normal tissue were 30.3% (27/89) and 65% (13/20), respectively. Cases with no p57KIP2 expression exhibited a significantly higher post-operative distant metastasis rate than those with p57KIP2 expression (37.9% vs. 14.8%; P = 0.01). DFS analysis showed that p57KIP2-/C-erbB-2μ tumors also exhibited a significantly higher post-operative distant metastasis rate than the other groups (66.7% vs. 29.2%; P = 0.007), as did p57KIP2-/p53μ tumors (64.3% vs. 22.7%; P = 0.001). Survival analysis revealed that p57KIP2 was associated with breast cancer-specific survival overall (P = 0.045, log-rank test). Subgroup analysis demonstrated that individuals with p57KIP2-/C-erbB-2μ tumors experienced significantly worse post-operative survival than those with p57KIP2- /C-erbB-2- or other tumors (P = 0.006, log-rank test). p57KIP2-/p53μ tumors were associated with significantly worse post-operative survival than p57KIP2-/p53- or other tumors (P = 0.001, log-rank test). Cox regression analysis showed that p57KIP2 was a non-independent prognostic factor for breast cancer (P = 0.303).
CONCLUSIONS
p57KIP2 is expressed at low levels in invasive breast cancer and is associated with better overall survival rate and disease-free survival in breast cancer patients, but it was a non-independent prognostic factor for breast cancer. Thus, the connection between p57KIP2/p53 and p57KIP2/C-erbB-2 may provide biomarkers for breast cancer.
影响因子：
10.5
作者：
MATSUOKA, S;EDWARDS, MC;ELLEDGE, SJ
通讯作者：
ELLEDGE, SJ
DOI：
10.1073/pnas.93.7.3026
发表时间：
1996-04-02
影响因子：
11.1
作者：
Matsuoka, S;Thompson, JS;Feinberg, AP
通讯作者：
Feinberg, AP