Effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, on the survival of mice infected with influenza virus
Effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, on the survival of mice infected with influenza virus
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DOI：
10.1016/s0166-3542(99)00048-0
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发表时间：
1999-12-15
影响因子：
7.6
通讯作者：
Komatsu, Y
中科院分区：
文献类型：
--
作者：
Mori, K;Kido, T;Komatsu, Y
用感染流感病毒的小鼠研究了日本中草药hohu -ekki-to （TJ-41）的抗病毒作用。在感染流感小鼠感染后第4天、感染前第7 ~ 2天和感染后第4天每天口服1次TJ-41可提高小鼠的存活率，延长平均存活天数，抑制支气管肺泡泡液（BALF）中病毒的生长，抑制肺指数（肺巩固）。在感染后第4天，给予TJ-41可降低IL-1 α、IL-6和GM-CSF的BALF浓度，但不能降低tnf - α或干扰素γ (ifn - γ)的浓度。此外，TJ-41在感染后第2天升高了BALF中ifn - α的水平。而TJ-41对流感病毒的体外生长没有抑制作用。这些结果表明，TJ-41对流感病毒感染的抑制作用是通过增强宿主免疫应答来实现的。(C) 1999 Elsevier Science B.V.版权所有
The antiviral effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, was investigated using mice infected with influenza virus. TJ-41 was found to increase the survival rate, prolong the mean survival days, suppress viral growth in bronchoalveolar labage fluid (BALF) and inhibit the lung index (lung consolidation) on day 4 after infection in mice infected with influenza, after the agent had been administered orally once daily from day 7 to 2 before infection and from day Oto 4 after infection. Administration of TJ-41 decreased the BALF concentrations of IL-1 alpha, IL-6 and GM-CSF, but not TNF-alpha or interferon-gamma (IFN-gamma), on day 4 after infection. In addition, TJ-41 elevated the level of IFN-alpha in BALF on day 2 after infection. Yet, TJ-41 did not show any inhibitory effect on the growth of influenza virus in vitro. These results suggest that TJ-41 exerts its inhibitory effect on influenza virus infection via enhancement of the host immune responses in this experimental murine system. (C) 1999 Elsevier Science B.V. All rights reserved.