A ventral CA1 to nucleus accumbens core engram circuit mediates conditioned place preference for cocaine
A ventral CA1 to nucleus accumbens core engram circuit mediates conditioned place preference for cocaine
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DOI：
10.1038/s41593-019-0524-y
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发表时间：
2019-09
影响因子：
25
通讯作者：
Yiming Zhou;Huiwen Zhu;Zhiyuan Liu;Xi Chen;Xiujuan Su;Chaonan Ma;Zhen Tian;Bing Huang;Enhui Yan;Xing Liu;Lan Ma
中科院分区：
文献类型：
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作者：
Yiming Zhou;Huiwen Zhu;Zhiyuan Liu;Xi Chen;Xiujuan Su;Chaonan Ma;Zhen Tian;Bing Huang;Enhui Yan;Xing Liu;Lan Ma
神经元集合体（称为记忆印迹细胞）在存储和检索记忆中的重要性越来越受到重视，但对这些记忆印迹细胞在神经回路中的运作方式知之甚少。在这里，我们标记在海马腹侧CA1区（vCA1）和可卡因条件性位置偏爱（CPP）训练的核心，并表明，vCA1的记忆痕迹项目优先的AcbC和记忆痕迹电路从vCA1的AcbC介导的记忆回忆。直接激活AcbC记忆印迹，同时抑制vCA 1记忆印迹足以用于可卡因CPP。AcbC印迹主要由D1中等多刺神经元组成，而不是D2中等多刺神经元。可卡因条件反射诱发的vCA 1 →AcbC脑迹回路的优先突触强化介导了可卡因CPP记忆的恢复。我们的数据表明，vCA 1记忆印迹存储特定的上下文信息，而AcbC D1记忆印迹及其下游网络存储可卡因奖励和相关的上下文信息，提供了一种潜在的机制，通过这种机制，可卡因CPP记忆被存储。
The importance of neuronal ensembles, termed engram cells, in storing and retrieving memory is increasingly being appreciated, but less is known about how these engram cells operate within neural circuits. Here we tagged engram cells in the ventral CA1 region of the hippocampus (vCA1) and the core of the nucleus accumbens (AcbC) during cocaine conditioned place preference (CPP) training and show that the vCA1 engram projects preferentially to the AcbC and that the engram circuit from the vCA1 to the AcbC mediates memory recall. Direct activation of the AcbC engram while suppressing the vCA1 engram is sufficient for cocaine CPP. The AcbC engram primarily consists of D1 medium spiny neurons, but not D2 medium spiny neurons. The preferential synaptic strengthening of the vCA1→AcbC engram circuit evoked by cocaine conditioning mediates the retrieval of cocaine CPP memory. Our data suggest that the vCA1 engram stores specific contextual information, while the AcbC D1 engram and its downstream network store both cocaine reward and associated contextual information, providing a potential mechanism by which cocaine CPP memory is stored.