Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells.
Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells.
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Tristetraprolin 与癌细胞中的 COX-2 mRNA 3 非翻译区结合。
DOI：
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发表时间：
2003
影响因子：
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通讯作者：
H. Sawaoka
中科院分区：
文献类型：
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作者：
O. Boutaud;D. Dixon;J. Oates;H. Sawaoka
几种类型的一致证据表明，可诱导的环氧合酶(COX-2)可以促进导致结肠癌的多步骤事件序列[1，2]。在85-90%的人类结直肠癌中，COX-2的水平升高[3]。它也表达在胃癌[4]、食道癌[5]、胰腺癌[6]、前列腺癌[7]、肺癌[8]和乳腺癌[9]。环氧合酶-2在结肠癌的发生发展中起着重要作用，但其过度表达的机制尚未完全阐明。COX-2的表达在转录水平上受细胞因子[10]和致癌信号通路的影响[11]。此外，转录后机制已被证明在致癌过程中调节COX-2的表达[12]，并增加或降低COX-2mRNA的稳定性[13]或降低[14]。COX-2基因的3‘非编码区含有22个拷贝的富含AU的保守序列元件，即AUUA五聚体。这种五聚体经常位于或靠近U富集区，与许多mRNAs的稳定性调节有关，包括原癌基因和细胞因子的mRNAs。已经确定了许多ARE结合蛋白，包括HUR、AUF-1/hnRNPD、TIA-1和Tristetraprolin，它们可以对mRNA的稳定性、翻译和亚细胞定位产生积极或消极的影响[15，16，17]。
Consistent evidence of several types indicates that the inducible cyclooxygenase (COX-2) can promote the multi-step sequence of events that lead to colon cancer [1,2]. Levels of COX-2 are increased in 85-90% of human colorectal adencarcinoma [3]. It also is expressed in cancers of the stomach [4], esophagus [5], pancreas [6], prostate [7], lung [8], and breast [9]. Whereas it is clear that COX-2 plays an important role in the initiation of colon cancer, the mechanisms that lead to its over-expression have not been fully elucidated. COX-2 expression is regulated at the transcriptional level in response to cytokines [10] and oncogenic signaling pathways [11]. Also, post-transcriptional mechanisms have been shown to play a role in the regulation of COX-2 expression during carcinogenesis [12], and to increase [13] or decrease [14] COX-2 mRNA stability. The 3’ UTR of COX-2 mRNA contains 22 copies of a conserved AU-rich sequence element (ARE), the AUUUA pentamer. This pentamer, frequently located in or near a U rich region, has been associated with the regulation of the stability of a number of mRNAs, including those of proto-oncogenes and cytokines. A number of ARE-binding proteins have been identified, including HuR, AUF- 1/hnRNPD, TIA-1, and tristetraprolin, that can exert either positive or negative effects on stability, translation and subcellular localization of the mRNA [15, 16, 17].
转化生长因子α对肠道中两个含锌指立即早期反应基因的调节。
DOI：
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发表时间：
1995
期刊：
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
影响因子：
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作者：
DuBois,RN;Bishop,PR;Graves-Deal,R;Coffey,RJ
通讯作者：
Coffey,RJ