Cold hibernated elastic memory foams for endovascular interventions
Cold hibernated elastic memory foams for endovascular interventions
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DOI：
10.1016/s0142-9612(02)00362-9
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发表时间：
2003-02-01
期刊：
影响因子：
14
通讯作者：
Raymond, J
中科院分区：
文献类型：
--
作者：
Metcalfe, A;Desfaits, AC;Raymond, J
冷冬眠弹性记忆（CHEM）聚氨酯泡沫是一种新型形状记忆聚合物自展开结构。在研究潜在的医学应用之前，对 CHEM 进行了标准细胞毒性和致突变性测试，以确保生物相容性。在体内，在八只狗的两条颈动脉上构建了侧壁动脉瘤。术中用 CHEM 块闭塞动脉瘤。在两只狗中，将 CHEM 栓塞与明胶海绵碎片栓塞进行比较。还使用 6F 经导管技术用 CHEM 封堵上颌内动脉 (Imax)。血管造影和病理学用于研究第 3 周和第 12 周时动脉瘤和 Imax 的演变。用 CHEM 泡沫栓塞的 Imax 在 3 周后仍保持闭塞。大多数用 CHEM 栓塞的动脉瘤在最初的血管造影中显示出小的残余新月形混浊，但血管造影评分在 3 周时明显更好。病理学证实动脉瘤颈部 CHEM 上形成厚厚的新内膜。 CHEM 的泡沫性质有利于参与新内膜形成的细胞向内生长。可以利用 CHEM 独特的物理特性设计用于血管内干预的新设备。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
Cold hibernated elastic memory (CHEM) polyurethane-based foam is a new shape memory polymeric self-deployable structure. Standard cytotoxicity and mutagenicity tests were conducted on CHEM in vitro, to ensure biocompatibility before studying potential medical applications. In vivo, lateral wall aneurysms were constructed on both carotid arteries of eight dogs. Aneurysms were occluded per-operatively with CHEM blocks. In two dogs, CHEM embolization was compared with gelatin sponge fragment embolization. Internal maxillary arteries (Imax) were also occluded with CHEM using a 6F transcatheter technique. Angiography and pathology were used to study the evolution of aneurysms and Imax at 3 and 12 weeks. Imax embolized with CHEM foam remained occluded at 3 weeks. Most aneurysms embolized with CHEM showed a small residual crescent of opacification at initial angiography, but angiographic scores were significantly better at 3 weeks. Thick neointima formation over the CHEM at the neck of aneurysms was demonstrated at pathology. The foamy nature of CHEM favours the ingrowth of cells involved in neointima formation. New devices for endovascular interventions could be designed using CHEM's unique physical properties. (C) 2002 Elsevier Science Ltd. All rights reserved.