Retinal oxygen kinetics imaging and analysis (ROKIA) based on the integration and fusion of structural-functional imaging
Retinal oxygen kinetics imaging and analysis (ROKIA) based on the integration and fusion of structural-functional imaging
复制标题
基于结构功能成像整合融合的视网膜氧动力学成像与分析（ROKIA）
DOI：
10.1364/boe.465991
复制
发表时间：
2022-10-01
影响因子：
3.4
通讯作者：
Zhou, Chuanqing
中科院分区：
文献类型：
--
作者：
Peng, Ximeng;Jin, Zi;Zhou, Chuanqing
视网膜是人体代谢最活跃的组织之一。视网膜氧动力学功能障碍与该病密切相关，具有重要的临床价值。视网膜氧动力学的动态成像和综合分析依赖于结构和功能成像的融合以及高时空分辨率。但目前还没有临床应用，特别是通过单一的成像设备。因此，本研究旨在将双波长成像与激光散斑对比成像相结合，开发一种视网膜氧动力学成像和分析（ROKIA）技术，实现高空间分辨率和动态测量的结构和功能分析，同时考虑外腔和管腔血管直径。ROKIA系统地评估了8项血管指标、4项血流指标和15项氧合指标。单器件方案克服了光学设计的不兼容性，协调了不同模态的视场和分辨率，降低了配准和图像处理算法的难度。更重要的是，许多指标（如氧气输送、氧气代谢、血管壁厚度等）来源于结构和功能信息的融合，是ROKIA独有的。本文提出的氧动力学分析技术，据我们所知，是第一次将血管指标、血流指标和氧合指标通过一个单一的系统进行演示，这将有可能成为疾病诊断和临床研究的有力工具。(c)根据Optica开放获取出版协议条款，2022年Optica出版集团
The retina is one of the most metabolically active tissues in the body. The dysfunction of oxygen kinetics in the retina is closely related to the disease and has important clinical value. Dynamic imaging and comprehensive analyses of oxygen kinetics in the retina depend on the fusion of structural and functional imaging and high spatiotemporal resolution. But it's currently not clinically available, particularly via a single imaging device. Therefore, this work aims to develop a retinal oxygen kinetics imaging and analysis (ROKIA) technology by integrating dual-wavelength imaging with laser speckle contrast imaging modalities, which achieves structural and functional analysis with high spatial resolution and dynamic measurement, taking both external and lumen vessel diameters into account. The ROKIA systematically evaluated eight vascular metrics, four blood flow metrics, and fifteen oxygenation metrics. The single device scheme overcomes the incompatibility of optical design, harmonizes the field of view and resolution of different modalities, and reduces the difficulty of registration and image processing algorithms. More importantly, many of the metrics (such as oxygen delivery, oxygen metabolism, vessel wall thickness, etc.) derived from the fusion of structural and functional information, are unique to ROKIA. The oxygen kinetic analysis technology proposed in this paper, to our knowledge, is the first demonstration of the vascular metrics, blood flow metrics, and oxygenation metrics via a single system, which will potentially become a powerful tool for disease diagnosis and clinical research.(c) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement