A Case of MPO-ANCA Positive Systemic Lupus Erythematosus Developed into Acute Kidney Injury
A Case of MPO-ANCA Positive Systemic Lupus Erythematosus Developed into Acute Kidney Injury
复制标题
DOI：
10.26502/acmcr.96550134
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Satoshi Suzuki;K. Ogiwara;T. Nishi;S. Sakuma;Maiko Akira;M. Iwasaki;Daisuke Honda;Hisatsugu Takahara;K. Ikeda;K. Yamaji;N. Tamura;H. Rinno;S. Morimoto
中科院分区：
文献类型：
--
作者：
Satoshi Suzuki;K. Ogiwara;T. Nishi;S. Sakuma;Maiko Akira;M. Iwasaki;Daisuke Honda;Hisatsugu Takahara;K. Ikeda;K. Yamaji;N. Tamura;H. Rinno;S. Morimoto
在治疗类风湿关节炎的过程中，检测到抗DNA抗体，诊断为系统性红斑狼疮，随后接受阿巴西普治疗，并获得缓解。 MPO-ANCA 阳性时注意到抗 DNA 抗体反弹和尿液异常。肾活检显示狼疮性肾炎；随后出现快速进展的肾小球肾炎，需要血浆分离术（双滤过血浆分离术）治疗，但没有取得缓解。然而，血浆交换疗法非常有效。这些结果表明，MPO-ANCA阳性狼疮性肾炎可能会变得严重，需要按照严重血管炎的治疗进行强化治疗。
During the course of treatment for rheumatoid arthritis, anti-DNA antibody was detected, and systemic lupus erythematosus was diagnosed, who was subsequently treated with abatacept—and remission was achieved. Rebound of elevated anti-DNA antibody and urinary abnormalities were noted with MPO-ANCA positivity. Renal biopsy revealed lupus nephritis; followed by the development of rapidly progressive glomerulonephritis, which required apheresis (double filtration plasmapheresis) therapy, although no response was achieved. However, plasma exchange therapy was highly effective. These results suggest that MPO-ANCA-positive lupus nephritis can become severe and require intensive treatment in accordance with the treatment for severe vasculitis.