URINARY FREE CORTISOL IN PSYCHOTIC DEPRESSION
URINARY FREE CORTISOL IN PSYCHOTIC DEPRESSION
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DOI：
10.1016/0006-3223(87)90126-0
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发表时间：
1987-01-01
影响因子：
10.6
通讯作者：
ANTON, RF
中科院分区：
文献类型：
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作者：
ANTON, RF
与无精神病性特征的抑郁症相比，有精神病性特征的抑郁症可能与较高的皮质醇分泌和更大的地塞米松非抑制血清皮质醇的可能性相关。在这项研究中，尿游离皮质醇（UFC），24小时皮质醇生产的一个敏感参数，地塞米松给药前和给药后，在32例抑郁症，18例精神病特征（MDPF），14例无精神病特征（MDD）。在地塞米松给药前和地塞米松给药后，显著更多数量的MDPF患者具有大于90 μ g/24小时的UFC排泄。尽管两组间除精神病特征外的一些临床变量存在差异，但这些变量不能解释UFC的差异。然而，MDPF组中的老年患者（> 55岁）导致了高UFC排泄，表明年龄和诊断之间存在相互作用。
Major depression with psychotic features may be associated with higher cortisol secretion and a greater probability of dexamethasone nonsuppression of serum cortisol than is found in major depression without psychotic features. In this study, urinary free cortisol (UFC), a sensitive parameter of 24-hr cortisol production, was examined both before and after dexamethasone administration in 32 patients with major depression, 18 with psychotic features (MDPF), and 14 without psychotic features (MDD). A significantly larger number of MDPF patients had UFC excretion greater than 90 .mu.g/24 hr before dexamethasone administration and greater than 20 .mu.g/24 hr after dexamethasone administration. Although some clinical variables other than psychotic features differed between the two groups, these could not account for the UFC differences. However, the older patients (> 55 years) in the MDPF group accounted for the high UFC excretion, suggesting an interaction between age and diagnosis.