Celebrating 25 years of NF-κB research.
Celebrating 25 years of NF-κB research.
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DOI：
10.1111/j.1600-065x.2012.01111.x
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发表时间：
2012-03
影响因子：
8.7
通讯作者：
Hayden MS
中科院分区：
文献类型：
--
作者：
Ghosh S;Hayden MS
核转录因子-κB（NF-κB）家族自发现以来的25年中一直是生物医学科学几乎所有领域的深入研究的主题。对这个单一转录因子家族的功能和调控的研究一直处于免疫学、癌症生物学和分子病理学研究的前沿，并与分子生物学、遗传工程、系统生物学和计算生物学的概念和技术进步齐头并进。在阐明NF-κB激活的触发因子、NF-κB通路的组分以及NF-κB的生理和病理生理功能方面取得了显著进展。因此，这一周年纪念是一个很好的机会，可借以重新审视构成如此多的努力和进展所依赖的基础的工作。这卷《免疫学评论》中的文章涵盖了许多关于NF-κB通路及其基本功能的已知内容。然而，每一次审查也都提请注意尚未解决的无数而且往往令人惊讶的根本问题。最后，在标记这一重要里程碑时，大多数评论者都分享了个人和历史叙述，记录了他们与NF-κB研究领域的联系。这些叙述提供了NF-κB研究早期的独特视角，当时该途径的许多基本基础都是在短时间内奠定的，并提供了特别的见解，了解该领域是如何通过来自不同生物学领域的科学移民的专业知识而丰富的，进一步突出了受这个单一转录因子家族影响的生物系统的惊人多样性。在这篇介绍性文章中，我们提出了一些最基本和根本的概念，以帮助不了解情况的人了解作为该问题其余部分特点的更详细的讨论。因此，这代表了对NF-κB信号通路及其生物学功能的严重删节介绍。在适当的情况下，我们指出读者对其他地方的评论在这个问题上，他们可能会获得更详细的见解和历史背景的各个方面的NF-κB。然而，为了与本期的格式保持一致，我（SG）开始提供一个我自己参与NF-κB的帐户。
In the 25 years since its discovery, the nuclear factor-κB (NF-κB) family of transcription factors has been the subject of intensive research in virtually all areas of biomedical science. Research into the function and regulation of this single transcription factor family has been at the forefront of studies in immunology, cancer biology, and molecular pathology, and has progressed hand in hand with conceptual and technological advances in molecular biology, genetic engineering, systems biology, and computational biology. The progress made in elucidating the triggers of NF-κB activation, the components of the NF-κB pathway, and characterization of the physiological and pathophysiological functions of NF-κB have been remarkable. This anniversary therefore represents an excellent opportunity to revisit the work that forms the foundation upon which so much effort and progress has been built. The articles in this volume of Immunological Reviews cover much of what is known about the NF-κB pathway and its basic function. Yet each review also draws attention to the myriad and often surprisingly fundamental issues that remain unresolved. Finally, in marking this important landmark, most reviewers have shared a personal and historical narrative documenting their connection to their area of study in NF-κB. These accounts offer a unique view of the early days of NF-κB research, when so much of the fundamental underpinnings of the pathway were laid down in short order, and provide particular insight into how this field was enriched through the expertise of scientific immigrants from disparate areas of biology, further highlighting the amazing diversity of biological systems influenced by this single transcription factor family.In this introductory article, we lay down some of the most basic and fundamental concepts in order to assist the uninitiated in gaining access to the more detailed discussions that characterize the rest of this issue. Thus, this represents a severely abridged introduction to the NF-κB signaling pathway and its biological function. Where appropriate, we point the reader towards reviews elsewhere in this issue from which they may gain more detailed insight and historical context to the various facets of NF-κB. However, in keeping with the format of this issue, I (SG) begin by offering an account of my own involvement with NF-κB.