Family history of cancer and associated risk of developing neuroendocrine tumors: A case-control study
Family history of cancer and associated risk of developing neuroendocrine tumors: A case-control study
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DOI：
10.1158/1055-9965.epi-07-0750
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发表时间：
2008-04-01
影响因子：
3.8
通讯作者：
Yao, James C.
中科院分区：
文献类型：
--
作者：
Hassan, Manal M.;Phan, Alexandria;Yao, James C.
背景：类癌是罕见的神经内分泌肿瘤（NET）。除了与多个内分泌肿瘤综合征1型相关的小比例外，很少有网络的家族性聚类。我们评估了净净家族史以及其他癌症对在五个不同位置产生的网的发展的影响。我们进行了一项回顾性，基于医院的病例对照研究，涉及740例组织学确认的网和924例健康对照。收集了有关癌症家族病史的信息，并使用无条件的逻辑回归分析来确定调整后的优势比（AOR）和95％的置信区间（CI）。分辨率：作者观察到与癌症与癌症与癌症和癌症的一级亲戚之间的显着关系在小肠内，胃，肺和胰腺上产生的网的发育； AOR（95％CI）分别为1.6（1.1-2.4），2.5（1.1-6.3），2.6（1.5-4.5）和1.8（1.1-3.1）。食管癌的一级家族史与胰腺网显着相关。 AOR，5.6（95％CL，1.1-29.6）。在患有大肠癌和前列腺癌的家庭病史之间，出现小肠网的风险增加了70％和130％。此外，患有肺癌家族史的个体患肺网的风险增加了2倍。结论：与一般癌症具有一级亲戚，尤其是网络，尤其是网络是网络的危险因素。在一级亲戚中，开发网的风险升高扩展到具有其他癌症家族史（不是净）家族史的人。这些结果表明，网络的风险可能由遗传因素部分解释。
Background: Carcinoids are rare neuroendocrine tumors (NET). Familial clusterings of NETS are rarely reported, except for a small proportion associated with multiple endocrine neoplasia syndrome type 1. We evaluated the effect of positive family history of NET as well as other cancers on the development of NETS arising at five different locations.Methods: We conducted a retrospective, hospital-based, case-control study involving 740 patients with histologically confirmed NETs and 924 healthy controls. Information on family history of cancer was collected, and unconditional logistic regression analysis was used to determine adjusted odds ratios (AOR) and 95 % confidence intervals (CI).Results: The authors observed a significant relationship between first-degree relatives with cancers and the development of NETS arising at the small intesLeonetine, stomach, lung, and pancreas; AORs (95% CI) were 1.6 (1.1-2.4), 2.5 (1.1-6.3), 2.6 (1.5-4.5), and 1.8 (1.1-3.1), respectively. A first-degree family history of esophageal cancer was significantly associated with pancreatic NETS; AOR, 5.6 (95% Cl, 1.1-29.6). There was a 70% and 130% increased risk of developing small intestinal NETS among subjects with family histories of colorectal cancer and prostate cancer, respectively. Moreover, individuals with a family history of lung cancer had a 2-fold increase in risk of developing pulmonary NETS.Conclusions: Having a first-degree relative with any cancer in general, and NET in particular, was a risk factor for NETs. The elevated risk of developing NETs extended to individuals with a family history of other cancers (not NETS) among first-degree relatives. These results suggested that risk of NETS may be partially explained by genetic factors.