First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies
First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies
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DOI：
10.1007/s00404-012-2501-5
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发表时间：
2012
影响因子：
2.6
通讯作者：
T. Yamada;M. Morikawa;Takahiro Yamada;R. Kishi;K. Sengoku;T. Endo;Tsuyoshi Saito;Kazutoshi Cho;H. Minakami
中科院分区：
文献类型：
--
作者：
T. Yamada;M. Morikawa;Takahiro Yamada;R. Kishi;K. Sengoku;T. Endo;Tsuyoshi Saito;Kazutoshi Cho;H. Minakami
ObjectivesTo determine whether a low serum folate level during the first trimester predicts subsequent late abortion，preterm birth，or fetal growth restriction（FGR）.Study designA prospective cohort study involving 5，075 women whose serum folate levels were measured during the first trimester.参与者被告知他们的血清叶酸levels.ResultsThe妊娠持续时间，出生体重，晚期流产/早产率，和FGR率并没有显着差异的四个组分类根据叶酸状态。平均血清叶酸水平在分娩时根据孕周分类的四分位数之间没有差异。20名叶酸缺乏的妇女中有19名足月分娩，婴儿出生体重为3.132 ± 321 g;只有1名婴儿患有FGR.ConclusionLow serum folate levels during the first trimester were not associated with the risk of late abnormal abortion，preterm birth，or FGR.
ObjectivesTo determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR).Study designA prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels.ResultsThe pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among the four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3.132 ± 321 g; only one infant had FGR.ConclusionLow serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR.