A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
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DOI：
10.1016/j.ccr.2006.10.008
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发表时间：
2006-12-01
期刊：
影响因子：
50.3
通讯作者：
Gray, Joe W.
中科院分区：
文献类型：
--
作者：
Neve, Richard M.;Chin, Koei;Gray, Joe W.
最近的研究表明，数以千计的基因可能有助于乳腺癌的病理生理时，基因组或表观基因组事件的失调。在这里，我们描述了一个模型“系统”来评估这些基因对乳腺癌子集的功能贡献。一般来说，51个乳腺癌细胞系的复发性基因组和转录特征反映了145个原发性乳腺肿瘤的复发性基因组和转录特征，尽管记录了一些显著差异。包含该系统的细胞系还表现出原发性肿瘤中发现的实质性基因组、转录和生物异质性。我们表明，使用曲妥珠单抗（赫赛汀）单药治疗作为一个例子，该系统可用于识别预测或指示对靶向治疗或其他生理扰动的反应的分子特征。
Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model "system" to appraise the functional contributions of these genes to breast cancer subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors, although some significant differences are documented. The cell lines that comprise the system also exhibit the substantial genomic, transcriptional, and biological heterogeneity found in primary tumors. We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations.