In utero exposure to polychlorinated biphenyls is associated with decreased fecundability in daughters of Michigan female fisheaters: a cohort study.
In utero exposure to polychlorinated biphenyls is associated with decreased fecundability in daughters of Michigan female fisheaters: a cohort study.
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一项队列研究显示，在子宫内接触多氯联苯与密歇根雌性食鱼者的女儿的生育能力下降有关。
DOI：
10.1186/s12940-016-0175-3
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发表时间：
2016-08-31
期刊：
影响因子：
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通讯作者：
Karmaus W
中科院分区：
文献类型：
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作者：
Han L;Hsu WW;Todem D;Osuch J;Hungerink A;Karmaus W
多项研究表明，成人接触环境有机氯与生育能力之间存在关系。然而，关于胎儿通过母亲血液接触有机氯以及成年女性后代的生育能力的数据很少。研究人员对两代食鱼母体队列的数据进行了研究，以评估雌性后代的生育力。 1973 年至 1991 年间，对密歇根州女性钓鱼者的多氯联苯 (PCB) 和 1,1-双-(4-氯苯基)-2,2-二氯乙烯 (DDE) 血清浓度进行了连续测量，并使用两种不同的方法来估计其女性后代的子宫内暴露情况。钓鱼者群体包括 391 名女性，其中 259 名提供了后代信息。在 213 名 20-50 岁的女儿中，有 151 名（71%）参与并提供了无保护性交时间间隔 (TUI) 的信息。女儿们报告了 308 起 TUI（重复观察），其中 288 起最终以怀孕告终。我们估计了血清-PCB 和血清-DDE 的受精率 (FR)，调整了混杂因素并考虑了重复测量。 FR 低于 1 表示怀孕时间较长。与 <2.5 µg/L 的血清 PCB 相比，2.5–7.4 µg/L 之间的血清 PCB 的 FR 为 0.60 [95% 置信区间 (CI) 0.36, 0.99]，血清 PCB >7.4 µg/L 的 FR 为 0.42 [95% CI 0.20, 0.88]。使用替代统计方法估计子宫血清 PCB 获得了类似的结果。当女性计划生育时，TUI 的关联性更强； 对于 2.5–7.4 µg/L 之间的血清 PCB，FR = 0.50，[95% CI 0.29, 0.89]；对于血清 PCB >7.4 µg/L，FR = 0.30 [95% CI 0.13, 0.68]。子宫内接触 DDE 与女儿的生育力之间没有关系。研究发现，食鱼雌性后代的生育能力下降与子宫内多氯联苯暴露有关，可能与卵母细胞和/或其他影响成年生殖能力的发育器官的内分泌干扰有关。本文的在线版本 (doi:10.1186/s12940-016-0175-3) 包含补充材料，可供授权用户使用。
Multiple studies have suggested a relationship between adult exposures to environmental organochlorines and fecundability. There is a paucity of data, however, regarding fetal exposure to organochlorines via the mother’s blood and fecundability of adult female offspring. Data from a two-generation cohort of maternal fisheaters was investigated to assess female offspring fecundability. Serum concentrations of polychlorinated biphenyls (PCBs) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (DDE) in Michigan female anglers were serially measured between 1973 and 1991 and used to estimate in utero exposure in their female offspring using two different methods. The angler cohort included 391 women of whom 259 provided offspring information. Of 213 daughters aged 20–50, 151 participated (71 %) and provided information for time intervals of unprotected intercourse (TUI). The daughters reported 308 TUIs (repeated observations), of which 288 ended in pregnancy. We estimated the fecundability ratio (FR) for serum-PCB and serum-DDE adjusting for confounders and accounting for repeated measurements. An FR below one indicates a longer time to pregnancy. Compared to serum-PCB of <2.5 μg/L, the FR was 0.60 for serum-PCB between 2.5–7.4 μg/L [95 % confidence intervals (CI) 0.36, 0.99], and 0.42 [95 % CI 0.20, 0.88] for serum-PCB >7.4 μg/L. Similar results were obtained using the alternative statistical method to estimate in utero serum-PCB. The association was stronger for TUIs when women planned a baby; FR = 0.50 for serum-PCB between 2.5–7.4 μg/L, [95 % CI 0.29, 0.89], and 0.30 [95 % CI 0.13, 0.68] for serum-PCB >7.4 μg/L. There was no relationship between in utero exposure to DDE and fecundability in daughters. Decreased fecundability in female offspring of fisheaters was found to be associated with PCB exposure in utero, possibly related to endocrine disruption in the oocyte and/or other developing organs influencing reproductive capacity in adulthood. The online version of this article (doi:10.1186/s12940-016-0175-3) contains supplementary material, which is available to authorized users.