Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1
Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1
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DOI：
10.1126/science.279.5355.1355
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发表时间：
1998-02-27
期刊：
影响因子：
56.9
通讯作者：
Hostetter, MK
中科院分区：
文献类型：
--
作者：
Gale, CA;Bendel, CM;Hostetter, MK
粘附和形成细丝的能力被认为有助于白色念珠菌的致病性，白色念珠菌是免疫功能低下患者真菌疾病的主要原因。Int1p是一个C。与脊椎动物整联蛋白相似性有限的白色念珠菌表面蛋白。INT 1在酿酒酵母中的表达足以指导这种通常不粘附的酵母与人上皮细胞的粘附。白念珠菌抑制菌丝生长、粘附于上皮细胞和毒力。因此，INT 1在白念珠菌中连接粘附、丝状生长和致病性。白色念珠菌和Int1p可能是抗真菌治疗的一个有吸引力的目标。
Adhesion and the ability to form filaments are thought to contribute to the pathogenicity of Candida albicans, the leading cause of fungal disease in immunocompromised patients. Int1p is a C. albicans surface protein with limited similarity to vertebrate integrins. INT1 expression in Saccharomyces cerevisiae was sufficient to direct the adhesion of this normally nonadherent yeast to human epithelial cells, Furthermore, disruption of INT1 in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice, Thus, INT1 links adhesion, filamentous growth, and pathogenicity in C. albicans and Int1p may be an attractive target for the development of antifungal therapies.