B cells are generated throughout life in humans.
B cells are generated throughout life in humans.
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DOI：
10.4049/jimmunol.156.2.866
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发表时间：
1996-01
影响因子：
4.4
通讯作者：
C. Nunez;N. Nishimoto;G. Gartland;L. Billips;P. Burrows;H. Kubagawa;M. Cooper;M. Cooper
中科院分区：
文献类型：
--
作者：
C. Nunez;N. Nishimoto;G. Gartland;L. Billips;P. Burrows;H. Kubagawa;M. Cooper;M. Cooper
对 B 细胞发育作为年龄函数的分析揭示了祖 B (pro-B)、前 B 细胞和 B 细胞在胎儿组织中相对广泛的分布，因此支持胚胎发育过程中 B 谱系细胞多灶起源的观点。从妊娠中期开始，骨髓是人类 B 细胞生成的主要场所。从妊娠中期到 80 岁，骨髓前体细胞与未成熟表型 B 细胞 (CD24highCD10+CD20lowIgD-) 的比例保持相对恒定。原 B 细胞中重组酶基因活性的持续存在进一步证明了骨髓中 B 细胞的持续产生。有趣的是，具有成熟表型的 B 细胞亚群 (CD24lowCD10-CD20highIgD+) 在儿童时期在骨髓中积累，并成为成人骨髓中的主要 B 细胞亚群。这种成熟的骨髓 B 细胞群可能代表在外周经过选择的再循环 B 细胞亚群。
This analysis of B cell development as a function of age reveals a relatively widespread distribution of progenitor B (pro-B), pre-B, and B cells in fetal tissues, and thus supports the idea of a multifocal origin of B lineage cells during embryonic development. From mid-gestation onward, the bone marrow is the major site of B cell generation in humans. A relatively constant ratio of bone marrow precursors to B cells of immature phenotype (CD24highCD10+CD20lowIgD-) is maintained from mid-gestation through the eighth decade of life. The persistence of recombinase gene activity in pro-B cells further attests the sustained production of B cells in bone marrow. Interestingly, a subpopulation of B cells with mature phenotype (CD24lowCD10-CD20highIgD+) accumulates in the bone marrow during childhood, and this becomes the predominant B cell subpopulation in adult bone marrow. This mature population of bone marrow B cells may represent a subpopulation of recirculating B cells that have undergone selection in the periphery.