Cyclic nucleotide signalling in malaria parasites.
Cyclic nucleotide signalling in malaria parasites.
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DOI：
10.1098/rsob.170213
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发表时间：
2017-12
期刊：
影响因子：
5.8
通讯作者：
Walker EM
中科院分区：
文献类型：
--
作者：
Baker DA;Drought LG;Flueck C;Nofal SD;Patel A;Penzo M;Walker EM
环核苷酸3′，5′-环腺苷酸（cAMP）和3′，5′-环鸟苷酸（cGMP）是存在于大多数动物细胞类型中的细胞内信使。它们通常介导细胞外刺激，通过激活各自的环核苷酸依赖性蛋白激酶PKA和PKG来驱动细胞功能的变化。疟疾寄生虫环核苷酸信号通路的酶成分已被确定，这些酶的遗传和生化研究进行了日期在此进行审查。已经非常清楚的是，环核苷酸在控制复杂的疟疾寄生虫生命周期的每个阶段中发挥着至关重要的作用。我们对环核苷酸信号传导参与疟疾寄生虫复杂生物学的理解仍处于起步阶段，但我们遗传工具的最新进展和对信号传导的日益关注将在未来几年取得更快的进展。
The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types. They usually mediate an extracellular stimulus to drive a change in cell function through activation of their respective cyclic nucleotide-dependent protein kinases, PKA and PKG. The enzymatic components of the malaria parasite cyclic nucleotide signalling pathways have been identified, and the genetic and biochemical studies of these enzymes carried out to date are reviewed herein. What has become very clear is that cyclic nucleotides play vital roles in controlling every stage of the complex malaria parasite life cycle. Our understanding of the involvement of cyclic nucleotide signalling in orchestrating the complex biology of malaria parasites is still in its infancy, but the recent advances in our genetic tools and the increasing interest in signalling will deliver more rapid progress in the coming years.
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影响因子：
2.7
作者：
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Langsley G
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