Respiratory muscle reserve in rats during heavy exercise.
Respiratory muscle reserve in rats during heavy exercise.
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DOI：
10.1152/jappl.1997.83.4.1405
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发表时间：
1997-10
影响因子：
3.3
通讯作者：
L. Gosselin;D. Megirian;J. Rodman;D. Mueller;G. Farkas
中科院分区：
文献类型：
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作者：
L. Gosselin;D. Megirian;J. Rodman;D. Mueller;G. Farkas
呼吸泵肌肉限制四足动物最大有氧能力的程度还不完全清楚。为了检查减少的呼吸肌储备对有氧能力的影响，在假手术、单侧或双侧半膈去神经（Daphnia）手术之前和之后测量健康Sprague-Dawley大鼠的全身峰值耗氧量（VO 2峰值）。采用分级跑台运动试验测定VO 2峰值。测试后，通过记录吸气时肌电活动的缺失来验证膈肌麻痹。术前，VO 2峰值平均为86、87和92 ml。kg-1 . min-1，分别为Sham、单侧和双侧Doppler组。术后2周，Sham组和单侧Doppler组的VO 2峰值均无显著变化。然而，术后2周，双侧多巴酚丁胺组的VO 2峰值下降约19%。这些研究结果强烈表明，大鼠的肺系统是这样设计的，在剧烈运动期间，剩余的呼吸泵肌肉能够补偿一个半横膈膜的损失，但不能同时补偿两个。
The extent to which the respiratory pump muscles limit maximal aerobic capacity in quadrupeds is not entirely clear. To examine the effect of reduced respiratory muscle reserve on aerobic capacity, whole body peak oxygen consumption (VO2 peak) was measured in healthy Sprague-Dawley rats before and after Sham, unilateral, or bilateral hemidiaphragm denervation (Dnv) surgery. VO2 peak was determined by using a graded treadmill running test. Hemidiaphragm paralysis was verified after testing by recording the absence of electromyographic activity during inspiration. Before surgery, VO2 peak averaged 86, 87, and 92 ml . kg-1 . min-1 for the Sham, unilateral, and bilateral Dnv groups, respectively. Two weeks after surgery, there was no significant change in VO2 peak for either the Sham or unilateral Dnv group. However, VO2 peak decreased approximately 19% in the bilateral Dnv group 2 wk after surgery. These findings strongly suggest that the pulmonary system in rats is designed such that during heavy exercise, the remaining respiratory pump muscles are able to compensate for the loss of one hemidiaphragm, but not of both.