Dendritic cell-targeted vaccines.
Dendritic cell-targeted vaccines.
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DOI：
10.3389/fimmu.2014.00255
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发表时间：
2014
影响因子：
7.3
通讯作者：
Delamarre L
中科院分区：
文献类型：
--
作者：
Cohn L;Delamarre L
尽管付出了巨大的努力，开发有效的疫苗来诱导针对细胞内病原体和癌细胞的强烈而持久的 T 细胞反应仍然是一个挑战。效应 CD8+ T 细胞反应的启动需要树突状细胞 (DC) 在称为交叉呈递的过程中将源自内化抗原的肽呈递到 I 类主要组织相容性复合体分子上。当前增强疫苗接种有效性的策略是将抗原直接递送至树突状细胞。这是通过使用针对 DC 表面内吞受体的单克隆抗体选择性靶向抗原来完成的。在这篇综述中，我们将讨论与此类疫苗设计相关的考虑因素：具有特殊功能的 DC 亚群的存在、抗原细胞内运输对交叉呈递的影响，以及 DC 接收的成熟信号对免疫反应结果的影响。
Despite significant effort, the development of effective vaccines inducing strong and durable T-cell responses against intracellular pathogens and cancer cells has remained a challenge. The initiation of effector CD8+ T-cell responses requires the presentation of peptides derived from internalized antigen on class I major histocompatibility complex molecules by dendritic cells (DCs) in a process called cross-presentation. A current strategy to enhance the effectiveness of vaccination is to deliver antigens directly to DCs. This is done via selective targeting of antigen using monoclonal antibodies directed against endocytic receptors on the surface of the DCs. In this review, we will discuss considerations relevant to the design of such vaccines: the existence of DC subsets with specialized functions, the impact of the antigen intracellular trafficking on cross-presentation, and the influence of maturation signals received by DCs on the outcome of the immune response.