Inhibitory effects of magnesium hydroxide on c-myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon.
Inhibitory effects of magnesium hydroxide on c-myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon.
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氢氧化镁对醋酸甲偶氮甲醇诱导的大鼠结肠c-myc表达和细胞增殖的抑制作用。
DOI：
10.1016/0304-3835(93)90190-k
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发表时间：
1993
期刊：
影响因子：
9.7
通讯作者：
H. Mori
中科院分区：
文献类型：
--
作者：
A. Wang;N. Yoshimi;T. Tanaka;H. Mori
研究了氢氧化镁对乙酸甲基偶氮甲醇 (MAM) 诱导的大鼠结肠粘膜上皮 c-myc 表达和细胞增殖的影响。将大鼠分为四组并进行如下处理：单独MAM乙酸盐（腹腔注射25mg/kg，五次，每周一次，持续5周），MAM乙酸盐并在饮食中饲喂0.2％氢氧化镁，单独氢氧化镁和不治疗。实验开始后4、8、16周，每组处死10只大鼠。氢氧化镁抑制了MAM诱导的c-myc原癌基因的表达，并且还抑制了MAM乙酸盐在起始和起始后结肠粘膜中诱导的溴脱氧尿苷（BrdU）和增殖细胞核抗原（PCNA）标记指数的增加。这些结果表明，氢氧化镁对MAM醋酸盐诱导的大鼠结肠癌的抗癌作用可能与抑制致癌物诱导的c-原癌基因的表达和细胞增殖有关。
The effects of magnesium hydroxide were examined on methylazoxymethanol (MAM) acetate-induced c-mycexpression and cell proliferation of colonic mucosal epithelium in rats. Rats were divided into four groups and treated as follows: MAM acetate alone (25 mg/kg i.p.injection, five times, once a week for 5 weeks), MAM acetate and feeding of 0.2% magnesium hydroxide in diet, magnesium hydroxide alone and non-treatment. At 4, 8 and 16 weeks after the start of experiment, 10 rats in each group were sacrificed. Magnesium hydroxide inhibited the MAM-induced expression of c-mycproto-oncogene, and also suppressed the increased bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) labelling indexes induced by MAM acetate in colon mucosa in initiation and post-initiation phase. These results suggest that the anti-carcinogenic effect of magnesium hydroxide on rat colon carcinogenesis induced by MAM acetate may be related to the inhibition of the carcinogen-induced expression of c-mycprotooncogene and cell proliferation.
耐药肝细胞模型中性别分化大鼠肝癌发生过程中c-myc、c-fos和c-rasHa原癌基因的表达。
影响因子：
4.7
作者：
Porsch-Hällström,I;Blanck,A;Eriksson,LC;Gustafsson,JA
通讯作者：
Gustafsson,JA