Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.
Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.
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DOI：
10.1016/j.bmcl.2008.01.031
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发表时间：
2008-02
影响因子：
2.7
通讯作者：
Chunhui Zhou;Jaeki Min;Zhigang Liu;A. Young;H. Deshazer;Tianshu Gao;Young‐Tae Chang;N. Kallenbach
中科院分区：
文献类型：
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作者：
Chunhui Zhou;Jaeki Min;Zhigang Liu;A. Young;H. Deshazer;Tianshu Gao;Young‐Tae Chang;N. Kallenbach
大量的研究促进了天然和合成抗菌肽作为抗生素制剂的潜在来源的发展。基于阳离子电荷、体积和亲脂性是决定这些肽抗菌活性的主要因素的概念，我们设计并筛选了几个基于1，3，5-三嗪作为模板的组合文库。一组化合物被鉴定为显示出有效的抗微生物活性以及低溶血活性。
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.